Boosting advanced doctoral training in innovative colon targeting drugs

Project Information

COLOTAN

Grant agreement ID: 956851

DOI

10.3030/956851

Project closed

EC signature date 19 August 2020

Start date 1 January 2021

End date 31 December 2024

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost

€ 3 533 108,04

EU contribution

€ 3 533 108,04

Coordinated by

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Open Research Data Pilot (3)

Mid-term report WP 3

Midterm report summarizing WP3 ESRs results

Mid-term report WP 2

Midterm report summarizing WP2 ESRs results

Mid-term report WP 1

Midterm report summarizing WP1 ESRs results

Documents, reports (3)

List of recruited ESRs

list of recruited ESRs

Project management handbook

Project management handbook and quality assurance

Reports on transferable skills

Reports on transferable skills acquired by ESRs (network-wide and local training)

Other (1)

Communication package

Communication package website graphical charts templates social networks

Publications

Peer reviewed articles (21)

Solidification and oral delivery of biologics to the colon- A review

Author(s): Kopp, Katharina Tatjana; Saerens, Lien; Voorspoels, Jody; Mooter, Guy Van den
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Publisher: Elsevier
DOI: 10.1016/j.ejps.2023.106523

Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

Author(s): A. L. Nichols, Z. Blumenfeld, L. Luebbert, H. J. Knox, A. K. Muthusamy, J. S. Marvin, C. H. Kim, S. N. Grant, D. P. Walton, B. N. Cohen, R. Hammar, L. L. Looger, P. Artursson, D. A. Dougherty, H. A. Lester
Published in: Journal of Neuroscience, 2023, ISSN 1529-2401
Publisher: Journal of Neuroscience
DOI: 10.1101/2022.08.09.502705

Spray drying for protein stabilization

Author(s): Katharina Tatjana Kopp, Maarten De Beer, Jody Voorspoels, Dorien Van Lysebetten, Guy Van den Mooter
Published in: International Journal of Pharmaceutics, Issue 677, 2025, Page(s) 125600, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125600

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition

Author(s): Pedro G.M. Canhão, Jan Snoeys, Suzy Geerinckx, Marjolein van Heerden, An Van den Bergh, Camden Holm, Jan Markus, Seyoum Ayehunie, Mario Monshouwer, Raymond Evers, Patrick Augustijns, Stephanie Kourula
Published in: European Journal of Pharmaceutical Sciences, 2025, Page(s) 107025, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2025.107025

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities

Author(s): Lea Gnatzy; George Ismailos; Maria Vertzoni; Christos Reppas
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Publisher: Elsevier
DOI: 10.1016/j.ejps.2023.106510

Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Author(s): Marco Tjakra, Nopdanai Chakrapeesirisuk, Magdalena Jacobson, Mikael E. Sellin, Jens Eriksson, Alexandra Teleki, Christel A. S. Bergström
Published in: Molecular Pharmaceutics, 2025, ISSN 1543-8384
Publisher: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.5c00298

Epithelial and microbial determinants of colonic drug distribution

Author(s): R. Hammar, M. E. Sellin, P. Artursson
Published in: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Publisher: Elsevier
DOI: 10.1016/j.ejps.2023.106389

Protein abundance of drug transporters and drug-metabolizing enzymes in paired healthy and tumor tissue from colorectal cancer patients

Author(s): Sebastian Steigert, Joachim Brouwers, Tim Vanuytsel, Sara Verbandt, Sabine Tejpar, Stefan Oswald, Patrick Augustijns
Published in: International Journal of Pharmaceutics, Issue 671, 2025, Page(s) 125216, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125216

Characterization of luminal contents from the fasted human proximal colon

Author(s): Sebastian Steigert, Joachim Brouwers, Kristin Verbeke, Tim Vanuytsel, Patrick Augustijns
Published in: European Journal of Pharmaceutical Sciences, Issue 200, 2024, Page(s) 106821, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106821

Development of a canine artificial colonic mucus model for drug diffusion studies

Author(s): V. Barmpatsalou, M. Tjakra, L. Li, I.R. Dubbelboer, E. Karlsson, B. Pedersen Lomstein, C.A.S. Bergström
Published in: European journal of pharmaceutical sciences, 2024, ISSN 1879-0720
Publisher: Elsevier
DOI: 10.1016/j.ejps.2024.106702

Disease‐Adaptive Drug Delivery to the Inflamed Intestinal Mucosa Using Poly(Lactic‐<i>Co</i>‐Glycolic Acid)‐cyclodextrin Hybrid Nanocarriers

Author(s): Jonas Schreiner, Felix E. B. Brettner, Sebastian Steigert, Annika Haessler, Raf Mols, Stefanie Gier, Nathalie Jung, Sarah Vogel‐Kindgen, Susanne Muschert, Patrick Augustijns, Maike Windbergs
Published in: Advanced Therapeutics, 2025, ISSN 2366-3987
Publisher: Wiley
DOI: 10.1002/adtp.202400368

The value of spray drying as stabilization process for proteins

Author(s): Katharina Tatjana Kopp, Maarten De Beer, Jody Voorspoels, Dorien Van Lysebetten, Guy Van den Mooter
Published in: International Journal of Pharmaceutics, Issue 674, 2025, Page(s) 125422, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125422

Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease

Author(s): Alessia Favaron, Youssef Abdalla, Laura E. McCoubrey, Laxmi Prasanna Nandiraju, David Shorthouse, Simon Gaisford, Abdul W. Basit, Mine Orlu
Published in: European Journal of Pharmaceutical Sciences, Issue 200, 2024, Page(s) 106845, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106845

Exploring the potential of human intestinal organoids: Applications, challenges, and future directions

Author(s): Inês A. Parente, Linda Chiara, Simona Bertoni
Published in: Life Sciences, Issue 352, 2024, Page(s) 122875, ISSN 0024-3205
Publisher: Elsevier BV
DOI: 10.1016/j.lfs.2024.122875

Do probiotic interventions improve female unexplained infertility? A critical commentary

Author(s): Alessia Favaron; Engin Turkgeldi; Moe Elbadawi; Simon Gaisford; Abdul W. Basit; Mine Orlu
Published in: Reproductive Biomedicine Online, 2024, ISSN 1472-6491
Publisher: Elsevier
DOI: 10.1016/j.rbmo.2023.103734

Can in vitro/in silico tools improve colonic concentration estimations for oral extended-release formulations? A case study with upadacitinib

Author(s): Alessia Favaron, Bart Hens, Maiara Camotti Montanha, Mark McAllister, Irena Tomaszewska, Shaimaa Moustafa, Marília Alvarenga de Oliveira, Abdul W. Basit, Mine Orlu
Published in: Journal of Controlled Release, Issue 370, 2024, Page(s) 182-194, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2024.04.024

Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products

Author(s): Harshad Jadhav; Patrick Augustijns; Christer Tannergren
Published in: Molecular Pharmaceutics, 2023, ISSN 1543-8392
Publisher: ACS Publication
DOI: 10.1021/acs.molpharmaceut.3c00683

Ai’s role in colon-targeted drug delivery

Author(s): Alessia Favaron, Youssef Abdalla, Abdul Basit, Mine Orlu
Published in: Expert Opinion on Drug Delivery, 2025, ISSN 1742-5247
Publisher: Ashley Publications Ltd.
DOI: 10.1080/17425247.2025.2465769

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Humans

Author(s): Christer Tannergren; Harshad Jadhav; Emma Eckernäs; Jonas Fagerberg; Patrick Augustijns; Erik Sjögren
Published in: European Journal of Pharmaceutics and Biopharmaceutics, 2023, Page(s) 144-159, ISSN 0939-6411
Publisher: Elsevier BV
DOI: 10.2139/ssrn.4358310

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Author(s): L. E. McCoubrey, A. Favaron, A. Awad, M. Orlu, S. Gaisford, A. W. Basit
Published in: Journal of Controlled Release 2023, 2023, Page(s) 1107-1126, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2022.12.029

Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug

Author(s): Laura E. McCoubrey, Chenghao Shen, Sydney Mwasambu, Alessia Favaron, Nannapat Sangfuang, Stavrina Thomaidou, Mine Orlu, Daniel Globisch, Abdul W. Basit
Published in: European Journal of Pharmaceutical Sciences, Issue 203, 2024, Page(s) 106922, ISSN 0928-0987
Publisher: Elsevier BV
DOI: 10.1016/j.ejps.2024.106922

Book chapters (1)

The Ageing Microbiome, Pharmaceutical Considerations, and Therapeutic Opportunities

Author(s): 10. A. Favaron, L. E. McCoubrey, M. Elbadawi, A. W. Basit, M. Orlu
Published in: Pharmaceutical Formulations for Older Patients, 2023
Publisher: Springer