Boosting advanced doctoral training in innovative colon targeting drugs

Información del proyecto

COLOTAN

Identificador del acuerdo de subvención: 956851

DOI

10.3030/956851

Proyecto cerrado

Fecha de la firma de la CE 19 Agosto 2020

Fecha de inicio 1 Enero 2021

Fecha de finalización 31 Diciembre 2024

Financiado con arreglo a

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Coste total

€ 3 533 108,04

Aportación de la UE

€ 3 533 108,04

Coordinado por

KATHOLIEKE UNIVERSITEIT LEUVEN
Belgium

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Open Research Data Pilot (3)

Mid-term report WP 3

Midterm report summarizing WP3 ESRs results

Mid-term report WP 2

Midterm report summarizing WP2 ESRs results

Mid-term report WP 1

Midterm report summarizing WP1 ESRs results

Documents, reports (3)

List of recruited ESRs

list of recruited ESRs

Project management handbook

Project management handbook and quality assurance

Reports on transferable skills

Reports on transferable skills acquired by ESRs (network-wide and local training)

Other (1)

Communication package

Communication package website graphical charts templates social networks

Publicaciones

Peer reviewed articles (21)

Solidification and oral delivery of biologics to the colon- A review

Autores: Kopp, Katharina Tatjana; Saerens, Lien; Voorspoels, Jody; Mooter, Guy Van den
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Editor: Elsevier
DOI: 10.1016/j.ejps.2023.106523

Selective Serotonin Reuptake Inhibitors Within Cells: Temporal Resolution in Cytoplasm, Endoplasmic Reticulum, and Membrane

Autores: A. L. Nichols, Z. Blumenfeld, L. Luebbert, H. J. Knox, A. K. Muthusamy, J. S. Marvin, C. H. Kim, S. N. Grant, D. P. Walton, B. N. Cohen, R. Hammar, L. L. Looger, P. Artursson, D. A. Dougherty, H. A. Lester
Publicado en: Journal of Neuroscience, 2023, ISSN 1529-2401
Editor: Journal of Neuroscience
DOI: 10.1101/2022.08.09.502705

Spray drying for protein stabilization

Autores: Katharina Tatjana Kopp, Maarten De Beer, Jody Voorspoels, Dorien Van Lysebetten, Guy Van den Mooter
Publicado en: International Journal of Pharmaceutics, Edición 677, 2025, Página(s) 125600, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125600

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition

Autores: Pedro G.M. Canhão, Jan Snoeys, Suzy Geerinckx, Marjolein van Heerden, An Van den Bergh, Camden Holm, Jan Markus, Seyoum Ayehunie, Mario Monshouwer, Raymond Evers, Patrick Augustijns, Stephanie Kourula
Publicado en: European Journal of Pharmaceutical Sciences, 2025, Página(s) 107025, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2025.107025

Managing the clinical effects of drug-induced intestinal dysbiosis with a focus to antibiotics: Challenges and opportunities

Autores: Lea Gnatzy; George Ismailos; Maria Vertzoni; Christos Reppas
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Editor: Elsevier
DOI: 10.1016/j.ejps.2023.106510

Optimized Artificial Colonic Mucus Enabling Physiologically Relevant Diffusion Studies of Drugs, Particles, and Delivery Systems

Autores: Marco Tjakra, Nopdanai Chakrapeesirisuk, Magdalena Jacobson, Mikael E. Sellin, Jens Eriksson, Alexandra Teleki, Christel A. S. Bergström
Publicado en: Molecular Pharmaceutics, 2025, ISSN 1543-8384
Editor: American Chemical Society
DOI: 10.1021/acs.molpharmaceut.5c00298

Epithelial and microbial determinants of colonic drug distribution

Autores: R. Hammar, M. E. Sellin, P. Artursson
Publicado en: European Journal of Pharmaceutical Sciences, 2023, ISSN 1879-0720
Editor: Elsevier
DOI: 10.1016/j.ejps.2023.106389

Protein abundance of drug transporters and drug-metabolizing enzymes in paired healthy and tumor tissue from colorectal cancer patients

Autores: Sebastian Steigert, Joachim Brouwers, Tim Vanuytsel, Sara Verbandt, Sabine Tejpar, Stefan Oswald, Patrick Augustijns
Publicado en: International Journal of Pharmaceutics, Edición 671, 2025, Página(s) 125216, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125216

Characterization of luminal contents from the fasted human proximal colon

Autores: Sebastian Steigert, Joachim Brouwers, Kristin Verbeke, Tim Vanuytsel, Patrick Augustijns
Publicado en: European Journal of Pharmaceutical Sciences, Edición 200, 2024, Página(s) 106821, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106821

Development of a canine artificial colonic mucus model for drug diffusion studies

Autores: V. Barmpatsalou, M. Tjakra, L. Li, I.R. Dubbelboer, E. Karlsson, B. Pedersen Lomstein, C.A.S. Bergström
Publicado en: European journal of pharmaceutical sciences, 2024, ISSN 1879-0720
Editor: Elsevier
DOI: 10.1016/j.ejps.2024.106702

Disease‐Adaptive Drug Delivery to the Inflamed Intestinal Mucosa Using Poly(Lactic‐<i>Co</i>‐Glycolic Acid)‐cyclodextrin Hybrid Nanocarriers

Autores: Jonas Schreiner, Felix E. B. Brettner, Sebastian Steigert, Annika Haessler, Raf Mols, Stefanie Gier, Nathalie Jung, Sarah Vogel‐Kindgen, Susanne Muschert, Patrick Augustijns, Maike Windbergs
Publicado en: Advanced Therapeutics, 2025, ISSN 2366-3987
Editor: Wiley
DOI: 10.1002/adtp.202400368

The value of spray drying as stabilization process for proteins

Autores: Katharina Tatjana Kopp, Maarten De Beer, Jody Voorspoels, Dorien Van Lysebetten, Guy Van den Mooter
Publicado en: International Journal of Pharmaceutics, Edición 674, 2025, Página(s) 125422, ISSN 0378-5173
Editor: Elsevier BV
DOI: 10.1016/j.ijpharm.2025.125422

Exploring the interactions of JAK inhibitor and S1P receptor modulator drugs with the human gut microbiome: Implications for colonic drug delivery and inflammatory bowel disease

Autores: Alessia Favaron, Youssef Abdalla, Laura E. McCoubrey, Laxmi Prasanna Nandiraju, David Shorthouse, Simon Gaisford, Abdul W. Basit, Mine Orlu
Publicado en: European Journal of Pharmaceutical Sciences, Edición 200, 2024, Página(s) 106845, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106845

Exploring the potential of human intestinal organoids: Applications, challenges, and future directions

Autores: Inês A. Parente, Linda Chiara, Simona Bertoni
Publicado en: Life Sciences, Edición 352, 2024, Página(s) 122875, ISSN 0024-3205
Editor: Elsevier BV
DOI: 10.1016/j.lfs.2024.122875

Do probiotic interventions improve female unexplained infertility? A critical commentary

Autores: Alessia Favaron; Engin Turkgeldi; Moe Elbadawi; Simon Gaisford; Abdul W. Basit; Mine Orlu
Publicado en: Reproductive Biomedicine Online, 2024, ISSN 1472-6491
Editor: Elsevier
DOI: 10.1016/j.rbmo.2023.103734

Can in vitro/in silico tools improve colonic concentration estimations for oral extended-release formulations? A case study with upadacitinib

Autores: Alessia Favaron, Bart Hens, Maiara Camotti Montanha, Mark McAllister, Irena Tomaszewska, Shaimaa Moustafa, Marília Alvarenga de Oliveira, Abdul W. Basit, Mine Orlu
Publicado en: Journal of Controlled Release, Edición 370, 2024, Página(s) 182-194, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2024.04.024

Approaches to Account for Colon Absorption in Physiologically Based Biopharmaceutics Modeling of Extended-Release Drug Products

Autores: Harshad Jadhav; Patrick Augustijns; Christer Tannergren
Publicado en: Molecular Pharmaceutics, 2023, ISSN 1543-8392
Editor: ACS Publication
DOI: 10.1021/acs.molpharmaceut.3c00683

Ai’s role in colon-targeted drug delivery

Autores: Alessia Favaron, Youssef Abdalla, Abdul Basit, Mine Orlu
Publicado en: Expert Opinion on Drug Delivery, 2025, ISSN 1742-5247
Editor: Ashley Publications Ltd.
DOI: 10.1080/17425247.2025.2465769

Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Humans

Autores: Christer Tannergren; Harshad Jadhav; Emma Eckernäs; Jonas Fagerberg; Patrick Augustijns; Erik Sjögren
Publicado en: European Journal of Pharmaceutics and Biopharmaceutics, 2023, Página(s) 144-159, ISSN 0939-6411
Editor: Elsevier BV
DOI: 10.2139/ssrn.4358310

Colonic drug delivery: Formulating the next generation of colon-targeted therapeutics

Autores: L. E. McCoubrey, A. Favaron, A. Awad, M. Orlu, S. Gaisford, A. W. Basit
Publicado en: Journal of Controlled Release 2023, 2023, Página(s) 1107-1126, ISSN 0168-3659
Editor: Elsevier BV
DOI: 10.1016/j.jconrel.2022.12.029

Characterising and preventing the gut microbiota's inactivation of trifluridine, a colorectal cancer drug

Autores: Laura E. McCoubrey, Chenghao Shen, Sydney Mwasambu, Alessia Favaron, Nannapat Sangfuang, Stavrina Thomaidou, Mine Orlu, Daniel Globisch, Abdul W. Basit
Publicado en: European Journal of Pharmaceutical Sciences, Edición 203, 2024, Página(s) 106922, ISSN 0928-0987
Editor: Elsevier BV
DOI: 10.1016/j.ejps.2024.106922

Book chapters (1)

The Ageing Microbiome, Pharmaceutical Considerations, and Therapeutic Opportunities

Autores: 10. A. Favaron, L. E. McCoubrey, M. Elbadawi, A. W. Basit, M. Orlu
Publicado en: Pharmaceutical Formulations for Older Patients, 2023
Editor: Springer