Towards optogenetic cortical implants for hearing impaired

Project Information

HearLight

Grant agreement ID: 964568

DOI 10.3030/964568

EC signature date 25 January 2021

Start date 1 April 2021

End date 31 March 2025

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 2 999 971,25

EU contribution € 2 999 971,25

Coordinated by

INSTITUT PASTEUR
France

Deliverables

Demonstrators, pilots, prototypes (3)

Flexible EcoG array for mice
High resolution μLED array
μLED array for mice

Task 1.2: Design, fabrication and in vivo testing of a μLED array for mice. (M1-12). Lead partner: UoSIn this tasks, a 2x2 mm, 10x10 μLED array delivering 480nm blue light (10mW/mm2) for patterned optogenetic stimulation of auditory cortex will be produced according to a current prototype available at UoS10, and optogenetic stimulation parameters already used at IP12. Spread and magnitude of cortical responses will be measured in vivo in ChR2 expressing mice at IP using penetrating silicon probes electrophysiology, leading to a calibrated optogenetic stimulation array [Deliverable D1.2]. If spatial resolution of responses is above expectancies (> 400μm half-width diameter, [Milestone 2]), a new design will be performed to narrow the emission cone and improve resolution for WP2 (see WP1.3).

Documents, reports (3)

Cochlear implant psychometry
Outreach Plan
Normal psychometry

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Project presentation video (5 min)

Project presentation video 5 min

Project Website

Publications

Peer reviewed articles (5)

Characterizing subcutaneous cortical auditory evoked potentials in mice

Author(s): Olivier Postal, Warren Bakay, Typhaine Dupont, Alexa Buck, Élodie Daoud, Christine Petit, Nicolas Michalski, Boris Gourévitch
Published in: Hearing Research, Issue Volume 422, 1 September 2022, 2022, ISSN 0378-5955
Publisher: Elsevier BV
DOI: 10.1016/j.heares.2022.108566

Flexible Transparent Electrodes Formed from Template-Patterned Thin-Film Silver

Author(s): Sihai Luo, Enkui Lian, Jiali He, John C. deMello
Published in: Advanced Materials, 2023, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300058

Protocol for implementing medial forebrain bundle stimulation as a reward for perceptual tasks in mice

Author(s): Antonin Verdier, Brice Bathellier, Sophie Bagur
Published in: STAR Protocols, Issue 4, 2023, Page(s) 102669, ISSN 2666-1667
Publisher: Cell Press
DOI: 10.1016/j.xpro.2023.102669

Design, Characterization, and In Vivo Application of Multi-Conductive Layer Organic Electrocorticography Probes

Author(s): Rémy Cornuéjols, Amélie Albon, Suyash Joshi, James Alexander Taylor, Martin Baca, Sofia Drakopoulou, Tania Rinaldi Barkat, Christophe Bernard, and Shahab Rezaei-Mazinani
Published in: ACS Applied Materials & Interfaces, Issue 15, 19, 2023, Page(s) 22854–22863, ISSN 1944-8252
Publisher: Amecican Chemical Society Publications
DOI: 10.1021/acsami.3c00553

Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation

Author(s): Antonin Verdier, Noémi Dominique, Déborah Groussard, Anna Aldanondo, Brice Bathellier, Sophie Bagur
Published in: Cell Reports Methods, Issue Volume 2, Issue 12, 2022, Page(s) 100355, ISSN 2667-2375
Publisher: Cell Press
DOI: 10.1101/2022.03.29.486230