Towards optogenetic cortical implants for hearing impaired

Informations projet

HearLight

N° de convention de subvention: 964568

DOI 10.3030/964568

Date de signature de la CE 25 Janvier 2021

Date de début 1 Avril 2021

Date de fin 31 Mars 2025

Financé au titre de

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Coût total € 2 999 971,25

Contribution de l’UE € 2 999 971,25

Coordonné par

INSTITUT PASTEUR
France

Livrables

Demonstrators, pilots, prototypes (3)

Flexible EcoG array for mice
High resolution μLED array
μLED array for mice

Task 1.2: Design, fabrication and in vivo testing of a μLED array for mice. (M1-12). Lead partner: UoSIn this tasks, a 2x2 mm, 10x10 μLED array delivering 480nm blue light (10mW/mm2) for patterned optogenetic stimulation of auditory cortex will be produced according to a current prototype available at UoS10, and optogenetic stimulation parameters already used at IP12. Spread and magnitude of cortical responses will be measured in vivo in ChR2 expressing mice at IP using penetrating silicon probes electrophysiology, leading to a calibrated optogenetic stimulation array [Deliverable D1.2]. If spatial resolution of responses is above expectancies (> 400μm half-width diameter, [Milestone 2]), a new design will be performed to narrow the emission cone and improve resolution for WP2 (see WP1.3).

Documents, reports (3)

Cochlear implant psychometry
Outreach Plan
Normal psychometry

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Project presentation video (5 min)

Project presentation video 5 min

Project Website

Publications

Peer reviewed articles (5)

Characterizing subcutaneous cortical auditory evoked potentials in mice

Auteurs: Olivier Postal, Warren Bakay, Typhaine Dupont, Alexa Buck, Élodie Daoud, Christine Petit, Nicolas Michalski, Boris Gourévitch
Publié dans: Hearing Research, Numéro Volume 422, 1 September 2022, 2022, ISSN 0378-5955
Éditeur: Elsevier BV
DOI: 10.1016/j.heares.2022.108566

Flexible Transparent Electrodes Formed from Template-Patterned Thin-Film Silver

Auteurs: Sihai Luo, Enkui Lian, Jiali He, John C. deMello
Publié dans: Advanced Materials, 2023, ISSN 0935-9648
Éditeur: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300058

Protocol for implementing medial forebrain bundle stimulation as a reward for perceptual tasks in mice

Auteurs: Antonin Verdier, Brice Bathellier, Sophie Bagur
Publié dans: STAR Protocols, Numéro 4, 2023, Page(s) 102669, ISSN 2666-1667
Éditeur: Cell Press
DOI: 10.1016/j.xpro.2023.102669

Design, Characterization, and In Vivo Application of Multi-Conductive Layer Organic Electrocorticography Probes

Auteurs: Rémy Cornuéjols, Amélie Albon, Suyash Joshi, James Alexander Taylor, Martin Baca, Sofia Drakopoulou, Tania Rinaldi Barkat, Christophe Bernard, and Shahab Rezaei-Mazinani
Publié dans: ACS Applied Materials & Interfaces, Numéro 15, 19, 2023, Page(s) 22854–22863, ISSN 1944-8252
Éditeur: Amecican Chemical Society Publications
DOI: 10.1021/acsami.3c00553

Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation

Auteurs: Antonin Verdier, Noémi Dominique, Déborah Groussard, Anna Aldanondo, Brice Bathellier, Sophie Bagur
Publié dans: Cell Reports Methods, Numéro Volume 2, Numéro 12, 2022, Page(s) 100355, ISSN 2667-2375
Éditeur: Cell Press
DOI: 10.1101/2022.03.29.486230