Towards optogenetic cortical implants for hearing impaired

Informazioni relative al progetto

HearLight

ID dell’accordo di sovvenzione: 964568

DOI 10.3030/964568

Data della firma CE 25 Gennaio 2021

Data di avvio 1 Aprile 2021

Data di completamento 31 Marzo 2025

Finanziato da

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Costo totale € 2 999 971,25

Contributo UE € 2 999 971,25

Coordinato da

INSTITUT PASTEUR
France

Risultati finali

Demonstrators, pilots, prototypes (3)

Flexible EcoG array for mice
High resolution μLED array
μLED array for mice

Task 1.2: Design, fabrication and in vivo testing of a μLED array for mice. (M1-12). Lead partner: UoSIn this tasks, a 2x2 mm, 10x10 μLED array delivering 480nm blue light (10mW/mm2) for patterned optogenetic stimulation of auditory cortex will be produced according to a current prototype available at UoS10, and optogenetic stimulation parameters already used at IP12. Spread and magnitude of cortical responses will be measured in vivo in ChR2 expressing mice at IP using penetrating silicon probes electrophysiology, leading to a calibrated optogenetic stimulation array [Deliverable D1.2]. If spatial resolution of responses is above expectancies (> 400μm half-width diameter, [Milestone 2]), a new design will be performed to narrow the emission cone and improve resolution for WP2 (see WP1.3).

Documents, reports (3)

Cochlear implant psychometry
Outreach Plan
Normal psychometry

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (2)

Project presentation video (5 min)

Project presentation video 5 min

Project Website

Pubblicazioni

Peer reviewed articles (5)

Characterizing subcutaneous cortical auditory evoked potentials in mice

Autori: Olivier Postal, Warren Bakay, Typhaine Dupont, Alexa Buck, Élodie Daoud, Christine Petit, Nicolas Michalski, Boris Gourévitch
Pubblicato in: Hearing Research, Numero Volume 422, 1 September 2022, 2022, ISSN 0378-5955
Editore: Elsevier BV
DOI: 10.1016/j.heares.2022.108566

Flexible Transparent Electrodes Formed from Template-Patterned Thin-Film Silver

Autori: Sihai Luo, Enkui Lian, Jiali He, John C. deMello
Pubblicato in: Advanced Materials, 2023, ISSN 0935-9648
Editore: United Nations Industrial Developement Organization
DOI: 10.1002/adma.202300058

Protocol for implementing medial forebrain bundle stimulation as a reward for perceptual tasks in mice

Autori: Antonin Verdier, Brice Bathellier, Sophie Bagur
Pubblicato in: STAR Protocols, Numero 4, 2023, Pagina/e 102669, ISSN 2666-1667
Editore: Cell Press
DOI: 10.1016/j.xpro.2023.102669

Design, Characterization, and In Vivo Application of Multi-Conductive Layer Organic Electrocorticography Probes

Autori: Rémy Cornuéjols, Amélie Albon, Suyash Joshi, James Alexander Taylor, Martin Baca, Sofia Drakopoulou, Tania Rinaldi Barkat, Christophe Bernard, and Shahab Rezaei-Mazinani
Pubblicato in: ACS Applied Materials & Interfaces, Numero 15, 19, 2023, Pagina/e 22854–22863, ISSN 1944-8252
Editore: Amecican Chemical Society Publications
DOI: 10.1021/acsami.3c00553

Enhanced perceptual task performance without deprivation in mice using medial forebrain bundle stimulation

Autori: Antonin Verdier, Noémi Dominique, Déborah Groussard, Anna Aldanondo, Brice Bathellier, Sophie Bagur
Pubblicato in: Cell Reports Methods, Numero Volume 2, Numero 12, 2022, Pagina/e 100355, ISSN 2667-2375
Editore: Cell Press
DOI: 10.1101/2022.03.29.486230