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Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Objective

Mental disorders represent one of the largest burdens for the European Health Care system, due to large number of patients and a lack of efficient treatment options. Today, drug treatment of mental disorders is characterized by severe adverse effects and suboptimal response in more than a third of the patients. Optimizing treatment is based on a trial-and-error approach, which combined with frequent multi-morbidities, often leads to polypharmacy and poor outcome. Due to limited understanding of the disease mechanisms that underlie mental disorders, new drugs with novel therapeutic targets are lacking, and existing treatments are ineffective for many people. It is therefore urgent that cutting-edge research approaches are deployed to develop innovative tools to individualize treatments using available psychiatric medication, and thus improve clinical outcomes and reduce costs for health care systems. The main goal of the multidisciplinary REALMENT project is to optimize treatment of mental disorders through novel precision medicine strategies based on current pharmaceutical options. REALMENT includes world leading research institutes and pharmaceutical industry at the very forefront of mental disorder research. REALMENT will achieve its objectives by exploiting population-scale Real-World Data (RWD) in combination with Randomized Clinical Trial (RCT) data available to the partners. Big data from populations (Nordic registries), cohorts (European biobanks), and eHealth samples (medical records), including whole genome genotypes (n=1.9 million), will be analysed in an EU-wide sustainable infrastructure using artificial intelligence and machine learning to develop prediction and stratification tools (precision psychiatry). These algorithms will be validated in large RCT data (n=10k) and re-phenotyping projects, and implemented in a clinical management platform (4MENT), which will be made available to provide decision support to clinicians to optimize therapeutic effects.

Field of science

  • /medical and health sciences/health sciences/health care services/ehealth
  • /natural sciences/computer and information sciences/artificial intelligence
  • /natural sciences/computer and information sciences/data science/big data

Call for proposal

H2020-SC1-2020-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITETET I OSLO
Address
Problemveien 5-7
0313 Oslo
Norway
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 445 817,50

Participants (13)

KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 528 945
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
REGION HOVEDSTADEN
Denmark
EU contribution
€ 422 133,75
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
ISLENSK ERFDAGREINING EHF
Iceland
EU contribution
€ 573 442,50
Address
Sturlugotu 8
101 Reykjavik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HELSINGIN YLIOPISTO
Finland
EU contribution
€ 269 961,25
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto
Activity type
Higher or Secondary Education Establishments
TARTU ULIKOOL
Estonia
EU contribution
€ 444 000
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
STICHTING VU
Netherlands
EU contribution
€ 424 942,50
Address
De Boelelaan 1105
1081 HV Amsterdam
Activity type
Higher or Secondary Education Establishments
CARDIFF UNIVERSITY
United Kingdom
EU contribution
€ 436 376,25
Address
Newport Road 30-36
CF24 ODE Cardiff
Activity type
Higher or Secondary Education Establishments
CORTECHS LABS INC
United States
EU contribution
€ 328 463,75
Address
4690 Executive Dr Suite 250
92121 San Diego
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
JANSSEN PHARMACEUTICA NV
Belgium
EU contribution
€ 502 168,75
Address
Turnhoutseweg 30
2340 Beerse
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
STICHTING BURO ECNP
Netherlands
EU contribution
€ 159 397,50
Address
Daltonlaan 400
3584 BK Utrecht
Activity type
Other
SMERUD MEDICAL RESEARCH INTERNATIONAL AS
Norway
EU contribution
€ 112 117,50
Address
Karenslyst Alle 6
0278 Oslo
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
DNV GL AS
Norway
EU contribution
€ 113 356,25
Address
Veritasveien 1
1363 Hovik
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITA DEGLI STUDI DI BARI ALDO MORO
Italy
EU contribution
€ 238 877,50
Address
Piazza Umberto I 1
70121 Bari
Activity type
Higher or Secondary Education Establishments