Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Project Information

REALMENT

Grant agreement ID: 964874

DOI

10.3030/964874

EC signature date 29 January 2021

Start date 1 June 2021

End date 30 November 2025

Funded under

• SOCIETAL CHALLENGES - Health, demographic change and well-being

Total cost

€ 6 000 000,00

EU contribution

€ 6 000 000,00

Coordinated by

UNIVERSITETET I OSLO
Norway

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (17)

Innovation, Intellectual Property (IP) and Knowledge Management Plan

Innovation Intellectual Property IP and Knowledge Management Plan

Risk Management Plan
Identification of relevant RWD sources in partner countries
Dissemination, Exploitation and Communication Plan yearly update M30

Dissemination, Exploitation and Communication Plan and yearly updates. Yearly updates shall include:- Newsletters- Updates of website- Report on scientific dissemination activities.- Report on public outreach.- Presentation of REALMENT findings to project stakeholders

An initial data freeze (Freeze 1) to be used for algorithm development
REALMENT Coordination team established
First Dissemination, Exploitation and Communication Plan done

First Dissemination Exploitation and Communication Plan done

Curated cross-border phenotypic data set
Minutes of the Annual Project Meeting Y3

Minutes of the Annual Project Meeting Y4

Quality Management Plan
Open access report on requirements for common data quality
Minutes of the Annual Project Meeting Y2
Replication of identified genotype-phenotype associations in an independent sample
Dissemination, Exploitation and Communication Plan yearly update M18

Dissemination Exploitation and Communication Plan and yearly updates Yearly updates shall include Newsletters Updates of website Report on scientific dissemination activities Report on public outreach Presentation of REALMENT findings to project stakeholders

Stakeholder input to design and user-friendly interface and clinical report design
Report of defined pharma trajectories
Tools and guidelines for data retrieval and sharing in place

Open Research Data Pilot (1)

Data Management Plan

Websites, patent fillings, videos etc. (1)

REALMENT website and Social Media channels operational

Publications

Peer reviewed articles (22)

Adolescent Psychedelic Use and Psychotic or Manic Symptoms

Author(s): Otto Simonsson, Miriam A. Mosing, Walter Osika, Fredrik Ullén, Henrik Larsson, Yi Lu, Laura W. Wesseldijk
Published in: JAMA Psychiatry, Issue 81, 2024, Page(s) 579, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2024.0047

Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores

Author(s): Djenifer B.KappelaSophie E.LeggeaLeonHubbardaIsabella R.WillcocksaKevin S.O’ConnelldRobert L.SmithdfEspenMoldenefOle A.AndreassendAdrianKingbJohnJansencMarinkaHelthuiscMichael J.OwenaMichael C.O’DonovanaJames T.R.WaltersaAntonio F.Pardiñasa
Published in: Biological Psychiatry, Issue Volume 93, Issue 2, 15 January 2023, 2023, Page(s) 149-156, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2022.07.014

Multivariate genetic analysis of personality and cognitive traits reveals abundant pleiotropy

Author(s): Guy Hindley, Alexey A. Shadrin, Dennis van der Meer, Nadine Parker, Weiqiu Cheng, Kevin S. O’Connell, Shahram Bahrami, Aihua Lin, Naz Karadag, Børge Holen, Thomas Bjella, Ian J. Deary, Gail Davies, W. David Hill, Jan Bressler, Sudha Seshadri, Chun Chieh Fan, Torill Ueland, Srdjan Djurovic, Olav B. Smeland, Oleksandr Frei, Anders M. Dale, Ole A. Andreassen
Published in: Nature Human Behaviour, Issue 7, 2023, Page(s) 1584-1600, ISSN 2397-3374
Publisher: nature human behaviour
DOI: 10.1038/s41562-023-01630-9

Epidemiological overview of major depressive disorder in Scandinavia using nationwide registers

Author(s): Joëlle A. Pasman, Joeri J. Meijsen, Marit Haram, Kaarina Kowalec, Arvid Harder, Ying Xiong, Thuy-Dung Nguyen, Andreas Jangmo, John R. Shorter, Jacob Bergstedt, Urmi Das, Richard Zetterberg, Ashley Tate, Paul Lichtenstein, Henrik Larsson, Ingvild Odsbu, Thomas Werge, Ted Reichborn-Kjennerud, Ole A. Andreassen, Patrick F. Sullivan, Alfonso Buil, Martin Tesli, Yi Lu
Published in: The Lancet Regional Health - Europe, Issue 29, 2023, Page(s) 100621, ISSN 2666-7762
Publisher: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2023.100621

Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation

Author(s): Guy Hindley, Oleksandr Frei, Alexey A. Shadrin, Weiqiu Cheng, Kevin S. O’Connell, Romain Icick, Nadine Parker, Shahram Bahrami, Naz Karadag, Daniel Roelfs, Børge Holen, Aihua Lin, Chun C. Fan, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Ole A. Andreassen
Published in: American Journal of Psychiatry, Issue 179, 2024, Page(s) 833-843, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.21101051

Impact of NFIB and CYP1A variants on clozapine serum concentration—A retrospective naturalistic cohort study on 526 patients with known smoking habits

Author(s): Hasan Çağın Lenk,Robert Løvsletten Smith,Kevin S. O'Connell,Marin M. Jukić,Marianne Kristiansen Kringen,Ole A. Andreassen,Magnus Ingelman-Sundberg,Espen Molden
Published in: Clin Transl Sci ., Issue 2023 Jan;16(1):62-72. doi: 10.1111/cts.13422. Epub 2022 Oct 7., 2023, Page(s) 62-72, ISSN 1752-8062
Publisher: Wiley
DOI: 10.1111/cts.13422

Polygenic overlap with body-mass index improves prediction of treatment-resistant schizophrenia

Author(s): Kevin S. O'Connell, Elise Koch, Hasan Çağın Lenk, Ibrahim A Akkouh, Guy Hindley, Piotr Jaholkowski, Robert Løvsletten Smith, Børge Holen, Alexey A. Shadrin, Oleksandr Frei, Olav B. Smeland, Nils Eiel Steen, Anders M. Dale, Espen Molden, Srdjan Djurovic, Ole A. Andreassen
Published in: Psychiatry Research, Issue 325, 2023, Page(s) 115217, ISSN 0165-1781
Publisher: Elsevier BV
DOI: 10.1016/j.psychres.2023.115217

How Real-World Data Can Facilitate the Development of Precision Medicine Treatment in Psychiatry

Author(s): Elise Koch, Antonio F. Pardiñas, Kevin S. O’Connell, Pierluigi Selvaggi, José Camacho Collados, Aleksandar Babic, Serena E. Marshall, Erik Van der Eycken, Cecilia Angulo, Yi Lu, Patrick F. Sullivan, Anders M. Dale, Espen Molden, Danielle Posthuma, Nathan White, Alexander Schubert, Srdjan Djurovic, Hakon Heimer, Hreinn Stefánsson, Kári Stefánsson, Thomas Werge, Ida Sønderby, Michael C. O’
Published in: Biological Psychiatry, 2024, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2024.01.001

Genetic Overlap Between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts

Author(s): Nadine Parker, Weiqiu Cheng, Guy F.L. Hindley, Kevin S. O’Connell, Sandeep Karthikeyan, Børge Holen, Alexey A. Shadrin, Zillur Rahman, Naz Karadag, Shahram Bahrami, Aihua Lin, Nils Eiel Steen, Thor Ueland, Pål Aukrust, Srdjan Djurovic, Anders M. Dale, Olav B. Smeland, Oleksandr Frei, Ole A. Andreassen
Published in: Biological Psychiatry, Issue 95, 2024, Page(s) 62-71, ISSN 0006-3223
Publisher: Elsevier BV
DOI: 10.1016/j.biopsych.2023.06.008

Polygenic liability for antipsychotic dosage and polypharmacy - a real-world registry and biobank study

Author(s): Elise Koch, Anders Kämpe, Maris Alver, Sindri Sigurðarson, Guðmundur Einarsson, Juulia Partanen, Robert L. Smith, Piotr Jaholkowski, Heidi Taipale, Markku Lähteenvuo, Nils Eiel Steen, Olav B. Smeland, Srdjan Djurovic, Espen Molden, null null, null null, Engilbert Sigurdsson, Hreinn Stefánsson, Kári Stefánsson, Aarno Palotie, Lili Milani, Kevin S. O’Connell, Ole A. Andreassen
Published in: Neuropsychopharmacology, Issue 49, 2024, Page(s) 1113-1119, ISSN 0893-133X
Publisher: Nature Publishing Group
DOI: 10.1038/s41386-023-01792-0

A comprehensive map of genetic relationships among diagnostic categories based on 48.6 million relative pairs from the Danish genealogy

Author(s): Georgios Athanasiadis, Joeri J. Meijsen, Dorte Helenius, Andrew J. Schork, Andrés Ingason, Wesley K. Thompson, Daniel H. Geschwind, Thomas Werge, Alfonso Buil
Published in: Proceedings of the National Academy of Sciences, Issue 119, 2022, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2118688119

Genetic Contribution to the Heterogeneity of Major Depressive Disorder: Evidence From a Sibling-Based Design Using Swedish National Registers

Author(s): Thuy-Dung Nguyen, Kaarina Kowalec, Joëlle Pasman, Henrik Larsson, Paul Lichtenstein, Christina Dalman, Patrick F. Sullivan, Ralf Kuja-Halkola, Yi Lu
Published in: American Journal of Psychiatry, Issue 180, 2024, Page(s) 714-722, ISSN 0002-953X
Publisher: American Psychiatric Publishing, Inc.
DOI: 10.1176/appi.ajp.20220906

Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders

Author(s): Piotr Jaholkowski, Alexey A. Shadrin, Andreas Jangmo, Evgeniia Frei, Markos Tesfaye, Guy F. L. Hindley, Marit Haram, Zillur Rahman, Lavinia Athanasiu, Nora Refsum Bakken, Børge Holen, Vera Fominykh, Gleda Kutrolli, Pravesh Parekh, Nadine Parker, Linn Rødevand, Viktoria Birkenæs, Srdjan Djurovic, Oleksandr Frei, Kevin S. O’Connell, Olav B. Smeland, Martin Tesli, Ole A. Andreassen
Published in: JAMA Psychiatry, Issue 80, 2023, Page(s) 738, ISSN 2168-622X
Publisher: American Medical Association
DOI: 10.1001/jamapsychiatry.2023.1137

Genetic predisposition and antipsychotic treatment effect on metabolic syndrome in schizophrenia: a ten-year follow-up study using the Estonian Biobank

Author(s): Maris Alver, Silva Kasela, Liina Haring, Laura Birgit Luitva, Krista Fischer, Märt Möls, Lili Milani
Published in: The Lancet Regional Health - Europe, Issue 41, 2024, Page(s) 100914, ISSN 2666-7762
Publisher: Lancet Regional Health Europe
DOI: 10.1016/j.lanepe.2024.100914

New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications

Author(s): Ole A. Andreassen, Guy F.L. Hindley, Oleksandr Frei, Olav B. Smeland
Published in: World Psychiatry, Issue 22, 2023, Page(s) 4-24, ISSN 1723-8617
Publisher: Masson Italia Periodici
DOI: 10.1002/wps.21034

Effects of a Novel UGT2B Haplotype and UGT1A4*3 Allele Variants on Glucuronidation of Clozapine In vivo

Author(s): Robert Løvsletten Smith; Birgit M. Wollmann; Marianne Kausberg; Sondre Mæland; Marit Tveito; Kevin O’Connell; Espen Molden; Marianne Kristiansen Kringen
Published in: Crossref, Issue 1, 2022, ISSN 1389-2002
Publisher: Bentham Science Publishers
DOI: 10.2174/1389200223666220201152953

Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Author(s): Álvaro Hernáez, Karoline H. Skåra, Christian M. Page, Vera R. Mitter, Marta H. Hernández, Per Magnus, Pål R. Njølstad, Ole A. Andreassen, Elizabeth C. Corfield, Alexandra Havdahl, Øyvind Næss, Ben Brumpton, Bjørn Olav Åsvold, Deborah A. Lawlor, Abigail Fraser, Maria Christine Magnus
Published in: BMC Medicine, Issue 22, 2024, ISSN 1741-7015
Publisher: BioMed Central
DOI: 10.1186/s12916-023-03223-9

Mediation and longitudinal analysis to interpret the association between clozapine pharmacokinetics, pharmacogenomics, and absolute neutrophil count

Author(s): Siobhan K. Lock, Sophie E. Legge, Djenifer B. Kappel, Isabella R. Willcocks, Marinka Helthuis, John Jansen, James T. R. Walters, Michael J. Owen, Michael C. O’Donovan, Antonio F. Pardiñas
Published in: Schizophrenia, Issue 9, 2023, ISSN 2754-6993
Publisher: Schizophrenia
DOI: 10.1038/s41537-023-00404-6

Shared Genetic Loci Between Schizophrenia and White Blood Cell Counts Suggest Genetically Determined Systemic Immune Abnormalities

Author(s): Nils Eiel Steen, Zillur Rahman, Attila Szabo, Guy F L Hindley, Nadine Parker, Weiqiu Cheng, Aihua Lin, Kevin S O’Connell, Mashhood A Sheikh, Alexey Shadrin, Shahram Bahrami, Sandeep Karthikeyan, Eva Z Hoseth, Anders M Dale, Pål Aukrust, Olav B Smeland, Thor Ueland, Oleksandr Frei, Srdjan Djurovic, Ole A Andreassen
Published in: Schizophrenia Bulletin, Issue 49, 2023, Page(s) 1345-1354, ISSN 0586-7614
Publisher: Oxford University Press
DOI: 10.1093/schbul/sbad082

Rare variants in pharmacogenes influence clozapine metabolism in individuals with schizophrenia

Author(s): Djenifer B. Kappel, Elliott Rees, Eilidh Fenner, Adrian King, John Jansen, Marinka Helthuis, Michael J. Owen, Michael C. O'Donovan, James T.R. Walters, Antonio F. Pardiñas
Published in: European Neuropsychopharmacology, Issue 80, 2024, Page(s) 47-54, ISSN 0924-977X
Publisher: Elsevier BV
DOI: 10.1016/j.euroneuro.2023.12.007

Investigating genetic overlap between antidepressant and lithium response and treatment resistance in major depressive disorder

Author(s): Yi Lu; Ying Xiong; Robert Karlsson; Jie Song; Kaarina Kowalec; Christian Rück; Robert Sigstrom; Lina Jonsson; Caitlin Clements; Evelyn Andersson; Julia Boberg; Cathryn Lewis; Patrick Sullivan; Mikael Landén
Published in: Crossref, Issue 17, 2023, ISSN 2693-5015
Publisher: translational psychiatry
DOI: 10.21203/rs.3.rs-2556941/v1

Psychometric Properties and Diagnostic Associations of the Short-Form Community Assessment of Psychic Experiences in a Population-Based Sample of 29 021 Adult Men

Author(s): Viktoria Birkenæs, Nora Refsum Bakken, Evgeniia Frei, Piotr Jaholkowski, Olav B Smeland, Markos Tesfaye, Ingrid Agartz, Ezra Susser, Michaeline Bresnahan, Espen Røysamb, Kjetil Nordbø Jørgensen, Ragnar Nesvåg, Alexandra Havdahl, Ole A Andreassen, Ida Elken Sønderby
Published in: Schizophrenia Bulletin, Issue 49, 2023, Page(s) 1229-1238, ISSN 0586-7614
Publisher: Oxford University Press
DOI: 10.1093/schbul/sbad074

Conference proceedings (1)

Genome-wide analyses reveal widespread genetic overlap between neurological and psychiatric disorders and a convergence of biological associations related to the brain

Author(s): Smeland, Olav B.; Kutrolli, Gleda; Bahrami, Shahram; Fominykh, Vera; Parker, Nadine; Hindley, Guy F. L.; Rødevand, Linn; Jaholkowski, Piotr; Tesfaye, Markos; Parekh, Pravesh; Elvsåshagen, Torbjørn; Grotzinger, Andrew D.; Steen, Nils Eiel; van der Meer, Dennis; O’Connell, Kevin S.; Djurovic, Srdjan; Dale, Anders M.; Shadrin, Alexey A.; Frei, Oleksandr; Andreassen, Ole A.
Published in: medRxiv, Issue 28, 2023, Page(s) 37503175
Publisher: Europe PMC