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Using real-world big data from eHealth, biobanks and national registries, integrated with clinical trial data to improve outcome of severe mental disorders

Descrizione del progetto

Migliorare il trattamento dei disturbi mentali

Poiché numerosi pazienti non hanno a disposizione opzioni di trattamento sufficienti, i disturbi mentali rappresentano uno dei più grandi oneri per il sistema sanitario europeo. I trattamenti attuali si basano su un approccio per tentativi ed errori; essendo le multi-morbilità frequenti, spesso ciò porta a politerapia e risultati insufficienti. Il progetto REALMENT, finanziato dall’UE, mira a ottimizzare il trattamento dei disturbi mentali tramite nuove strategie farmacologiche di precisione basate su opzioni farmaceutiche attuali. Gli sforzi del progetto porteranno istituti di ricerca leader a livello mondiale e l’industria farmaceutica in prima linea nella ricerca sui disturbi mentali.

Obiettivo

Mental disorders represent one of the largest burdens for the European Health Care system, due to large number of patients and a lack of efficient treatment options. Today, drug treatment of mental disorders is characterized by severe adverse effects and suboptimal response in more than a third of the patients. Optimizing treatment is based on a trial-and-error approach, which combined with frequent multi-morbidities, often leads to polypharmacy and poor outcome. Due to limited understanding of the disease mechanisms that underlie mental disorders, new drugs with novel therapeutic targets are lacking, and existing treatments are ineffective for many people. It is therefore urgent that cutting-edge research approaches are deployed to develop innovative tools to individualize treatments using available psychiatric medication, and thus improve clinical outcomes and reduce costs for health care systems. The main goal of the multidisciplinary REALMENT project is to optimize treatment of mental disorders through novel precision medicine strategies based on current pharmaceutical options. REALMENT includes world leading research institutes and pharmaceutical industry at the very forefront of mental disorder research. REALMENT will achieve its objectives by exploiting population-scale Real-World Data (RWD) in combination with Randomized Clinical Trial (RCT) data available to the partners. Big data from populations (Nordic registries), cohorts (European biobanks), and eHealth samples (medical records), including whole genome genotypes (n=1.9 million), will be analysed in an EU-wide sustainable infrastructure using artificial intelligence and machine learning to develop prediction and stratification tools (precision psychiatry). These algorithms will be validated in large RCT data (n=10k) and re-phenotyping projects, and implemented in a clinical management platform (4MENT), which will be made available to provide decision support to clinicians to optimize therapeutic effects.

Campo scientifico (EuroSciVoc)

CORDIS classifica i progetti con EuroSciVoc, una tassonomia multilingue dei campi scientifici, attraverso un processo semi-automatico basato su tecniche NLP.

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Invito a presentare proposte

H2020-SC1-BHC-2018-2020

Vedi altri progetti per questo bando

Bando secondario

H2020-SC1-2020-Single-Stage-RTD

Meccanismo di finanziamento

RIA - Research and Innovation action

Coordinatore

UNIVERSITETET I OSLO
Contribution nette de l'UE
€ 986 000,66
Indirizzo
PROBLEMVEIEN 5-7
0313 Oslo
Norvegia

Mostra sulla mappa

Tipo di attività
Higher or Secondary Education Establishments
Collegamenti
Costo totale
€ 1 534 523,16

Partecipanti (15)