Descripción del proyecto
Desarrollo de las herramientas necesarias para luchar contra los patógenos farmacorresistentes
La resistencia a los antibióticos constituye una de las principales preocupaciones de la medicina moderna. Pese a que los antibióticos han salvado incontables vidas, están surgiendo patógenos farmacorresistentes que ponen en peligro el bienestar de las generaciones venideras. Por ello, se hace necesario un enfoque radical que permita mitigar los efectos de este tipo de infecciones sobre la asistencia sanitaria en todo el mundo. El proyecto financiado con fondos europeos REVERSE desarrollará un marco para ayudar a prevenir y gestionar los patógenos farmacorresistentes a la vez que se limita su impacto sobre los sistemas de salud. Utilizará un método multidisciplinario para ampliar los conocimientos actuales sobre los patógenos farmacorresistentes que podría servir de base para la formulación de estrategias nuevas encaminadas a reducir sus efectos sobre la salud y la economía europea.
Objetivo
Emerging antibiotic resistance has become an endemic problem, slowly increasing under the radar and depriving future generations of effective therapies. The goal of REVERSE is to develop and implement cost-effective strategies and tools for the prevention and clinical management of healthcare-associated infections due to multidrug-resistant pathogens, and to reduce the burden of antimicrobial resistance in high prevalence healthcare settings. To achieve these goals, REVERSE will use a mixed-methods approach combining quantitative research with implementation science and economic analysis. The aim is to produce results that go beyond the evidence-base we have today. REVERSE will answer the question about real-life effectiveness of infection prevention and control programmes in combination with antibiotic stewardship on healthcare-associated infections due to multidrug-resistant microorganisms. It will offer implementation strategies to the participating hospitals but also study the effectiveness of external implementation support in a hybrid implementation-effectiveness trial. REVERSE will develop a novel health-economic framework that allows for incorporating of effect of changes in the use of a range of antibiotics on antibiotic resistant infections, and estimating long-term population effects, to integrate both into cost-effectiveness analyses. It will be able to conclude on effectiveness and applicability of prevention strategies in lower-resource settings by cross-checking its programmes with activities in low-and-middle income countries. Four European countries will have a platform of highly experienced hospitals to build on and expand a national network for combatting antibiotic resistance. REVERSE will produce tools and bundles on infection prevention and control, antibiotic stewardship and implementation support. Massive online open courses and other dissemination strategies will make the findings of REVERSE accessible to a wide range of stakeholders.
Ámbito científico
- engineering and technologyelectrical engineering, electronic engineering, information engineeringinformation engineeringtelecommunicationsradio technologyradar
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistancemultidrug resistance
- natural sciencesbiological sciencesmicrobiology
- medical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistance
Palabras clave
Programa(s)
Convocatoria de propuestas
Consulte otros proyectos de esta convocatoriaConvocatoria de subcontratación
H2020-SC1-2020-Single-Stage-RTD
Régimen de financiación
RIA - Research and Innovation actionCoordinador
8006 Zurich
Suiza