Engineering protein O-Glycosylation for the production of receptor blockers

Informazioni relative al progetto

ID dell’accordo di sovvenzione: BIO4950138

Progetto chiuso

Data di avvio 1 Gennaio 1996

Data di completamento 31 Dicembre 1998

Finanziato da

• Specific research, technological development and demonstration programme in the field of biotechnology, 1994-1998

Costo totale Nessun dato

Contributo UE Nessun dato

Coordinato da

Forschungszentrum Jülich GmbH
Germany

Exploitable results

Engineering protein O-glycosylation for the production of receptor blockers

Production methods for mucin type receptor blockers, namely O-glycosylated peptides, have been developed. In vivo and in vitro synthesis of selectin blockers are considered. In vivo synthesis by installation of new glycosylation pathways in CHO-cells and in vitro synthesis of O-glycans using glycosyltransferases produced at an industrial scale in CHO-cells, combined with recycling pathways for sugar nucleotide substrates have been studied.