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CORDIS - Risultati della ricerca dell’UE
CORDIS
Contenuto archiviato il 2024-04-30

Development and clinical test of a MR- compatible stereotactic probe for laser-neurosurgery with real-time monitoring

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Summary: Device for measuring the position and direction of a laser beam and automatically repositioning the laser to a desired position and direction. The device consists of two position sensors, two steerable mirrors, and a control software. Once a desired beam direction is defined by the position sensors, the direction can be reproduced with an accuracy of better than 50 microns (position) and better than 0.2 mrad (direction), respectively. The system can be used in scientific, industrial, and medical laser arrangements to reproduce a desred alignment with highest accuracy. It can be helpful in a large number of applications. The system is available as a prototype, which is embedded in a medical laser arrangement.
Summary: Device for pressure-controlled rinsing and aspiration of sterile physiological saline for the application in neurosurgery. The device comprises medical tubing pumps and miniaturized pressure sensors as well as a control software. It is capable of rinsing an intracranial cavity with a flow rate of up to 150 ml/min while keeping the intracranial pressure at non-critical values. The system supports the minimal invasive laser resection of brain tumours in that way, that it removes ablated tumour particles out of the operation cavity. End-users for the device are neurosurgeons, who work with endoscopes.
Summary: Operating system comprising a powerful picosecond laser, a beam delivery system, a computer-controlled application unit, operation planning software and real-time monitoring devices. The system enables the minimal-invasive resection of deep-seated brain tumours with high precision in an interventional MRI scanner. The combination of stereotactic procedures with the precision of ultrashort-pulsed lasers is a new approach for the treatment of brain tumours. End-users for the complex operating system are neurosurgical centers with high experience in stereotactic operation techniques and with a high-standard environment.
Summary: Devices and services for the support of various diagnostic and therapeutic procedures, which fulfill the mechanical and electronical requirements of medical magnetic resonance imaging. Devices include surgical equipment, stereotactic positioning apparatus, special electronical filters, all built of MR compatible materials. Services include the consulting of radiologists, neurosurgeons or medical physicists during the planning or introduction of custom-made diagnostic and therapeutic procedures as well as the acquisition of special components. Consulting will be organised in direct contact with the responsible personnel.
Summary: Operating system comprising a powerful picosecond laser, a beam delivery system, a computer-controlled application unit, operation planning software. The application unit is a endoscopic laser probe with a small diameter, which allows the insertion into critical structures of the human brain. The probe can be introduced stereotactically into the desired area. The system enables minimal-invasive procedures in the brain. Potential applications are Parkinson disease, Huntington disease or several kinds of dyskinesia. The system is based on precision laser ablation of volumes of up to 0,1 ml.
Summary: Small and compact quality assurance head phantom for measuring the spatial distortions of MR images simultaneously in three dimensions. The prototype phantom consists of a waterproof square box of acrylic glass (PMMA = polymethylmethacrylat, PLEXIGLAS GS) with a wall thickness of 10 mm and a dimension of 190 mm x 190 mm x 190 mm, according to the inner diameter of the head-coil of the MR-scanner. Inside this box is a three dimensional array of solid glass rods with a diameter of 3 mm. The space between the rods is 20 mm in each dimension. These rods are the fiducial markers in the X, Y, and Z-plane and the position is well known with an accuracy of ? 0.2 mm. To make the fiducials visible for MRI the box is filled with a dilute copper sulphate solution. The solid glass rods are visible as hypointense spots in the MR-image. The image coordinate (for example U, V in the Z-plane) of each fiducial can be measured in the image. Since the exact position of each rod (for example coordinates X, Y in the Z-plane) is known , the position in the image of the phantom reflects the geometrical distortion in the image plane and may be used to calculate the coordinate transformation that mathematically describes the distortion. With this coordinate transformation the MR-images can be corrected. This device is useful for quality assurance in MR-scanner or even CT-scanner if a high image accuracy in any image plane is needed. A prototype of the quality assurance head phantom is available and the software for evaluation and correction of the images is still under construction.
Summary: Small-aperture confocal laser-scanning microscope for the detection of inner surfaces of operation cavities or any other hollow or liquid-filled objects. The device is adapted to a tube system, which is introduced into the hollow object up to a length of 12 cm. The surface is detected in the geometry of a coil. The resolution is in the order of 35 µm. The real-time detection field has a height of 0.7 mm, which can be increased, if a shorter introduction length is acceptable. The images are recorded and presented on the monitor by a special software. The image data is availabe for digital image processing if required.

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