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An apparatus for closed-loop hyperthermia therapy

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The main objective of the intended research project is to carry on a feasibility study of an innovative product for minimally invasive therapy (MIT) of cancer by hyperthermia. Hyperthermia is a therapy known and used for about 10 years in the treatment of cancer pathologies. It makes use of electromagnetic (usually RF) waves which produce heat in localised regions of the body. Several studies demonstrated that , in order to achieve the best therapeutic effects for the patient and, at the same time less pain for him/her, it is essential to know the real temperature distributions inside and outside the treated zone. The prime proposer of this project is currently manufacturing a system for hyperthermia featured by advanced solutions and well accepted in the national market. The main goal of the project is to develop an improved version of this apparatus machine based on a true technological innovation: in fact the new system will incorporate novel microsensors for measuring the temperature distribution in the body in a minimally invasive way. In particular the temperature microsensors will be able to: a) monitor the temperature distribution inside and around the tumour heated by the RF source, b) to allow closed-loop control of the RF source. These features are a real breakthrough in the field, and may allow the new apparatus to outperform all existing competing systems. In fact, present systems for hyperthermia are not widely accepted by the medical community due to the fact that they are unable to control accurately the temperature distribution in the body resulting from RF irradiation. Temperature measurements are carried on either inaccurately, as by means of non invasive techniques; or expensively, as by means of fiberoptic sensors; or painfully, as by means of temperature probes inserted in the tissues by needles (usually 1,5 mm diameter). The new microsensors that will be developed during this project will be incorporated in needles with an external diameter of 600 mm and a length of 30-75 mm cm of length. Each microprobe will have 4-5 measurement points and an accuracy of 0,1°C. The probes will be manufactured in large scale so as to reduce their cost considerably. The new apparatus will also include novel RF antennas for internal RF heating, featured by small dimensions and by the possibility of changing their shape adaptively using microactuators. The combination of these technological innovation, and the development of improved theoretical models for local tissue heating, will ultimately allow to design an apparatus able to control in closed-loop the hyperthermia process.
The main objective of the intended research project is to carry on a feasibility study of an innovative product for minimally invasive therapy (MIT) of cancer by hyperthermia. Hyperthermia is a therapy known and used for about 10 years in the treatment of cancer pathologies. It makes use of electromagnetic (usually RF) waves which produce heat in localised regions of the body. Several studies demonstrated that , in order to achieve the best therapeutic effects for the patient and, at the same time less pain for him/her, it is essential to know the real temperature distributions inside and outside the treated zone. The prime proposer of this project is currently manufacturing a system for hyperthermia featured by advanced solutions and well accepted in the national market. The main goal of the project is to develop an improved version of this apparatus machine based on a true technological innovation: in fact the new system will incorporate novel microsensors for measuring the temperature distribution in the body in a minimally invasive way. In particular the temperature microsensors will be able to: a) monitor the temperature distribution inside and around the tumour heated by the RF source, b) to allow closed-loop control of the RF source. These features are a real breakthrough in the field, and may allow the new apparatus to outperform all existing competing systems. In fact, present systems for hyperthermia are not widely accepted by the medical community due to the fact that they are unable to control accurately the temperature distribution in the body resulting from RF irradiation. Temperature measurements are carried on either inaccurately, as by means of non invasive techniques; or expensively, as by means of fiberoptic sensors; or painfully, as by means of temperature probes inserted in the tissues by needles (usually 1,5 mm diameter). The new microsensors that will be developed during this project will be incorporated in needles with an external diameter of 600 mm and a length of 30-75 mm cm of length. Each microprobe will have 4-5 measurement points and an accuracy of 0,1°C. The probes will be manufactured in large scale so as to reduce their cost considerably. The new apparatus will also include novel RF antennas for internal RF heating, featured by small dimensions and by the possibility of changing their shape adaptively using microactuators. The combination of these technological innovation, and the development of improved theoretical models for local tissue heating, will ultimately allow to design an apparatus able to control in closed-loop the hyperthermia process.
The main objective of the intended research project is to carry on a feasibility study of an innovative product for minimally invasive therapy (MIT) of cancer by hyperthermia. Hyperthermia is a therapy known and used for about 10 years in the treatment of cancer pathologies. It makes use of electromagnetic (usually RF) waves which produce heat in localised regions of the body. Several studies demonstrated that , in order to achieve the best therapeutic effects for the patient and, at the same time less pain for him/her, it is essential to know the real temperature distributions inside and outside the treated zone. The prime proposer of this project is currently manufacturing a system for hyperthermia featured by advanced solutions and well accepted in the national market. The main goal of the project is to develop an improved version of this apparatus machine based on a true technological innovation: in fact the new system will incorporate novel microsensors for measuring the temperature distribution in the body in a minimally invasive way. In particular the temperature microsensors will be able to: a) monitor the temperature distribution inside and around the tumour heated by the RF source, b) to allow closed-loop control of the RF source. These features are a real breakthrough in the field, and may allow the new apparatus to outperform all existing competing systems. In fact, present systems for hyperthermia are not widely accepted by the medical community due to the fact that they are unable to control accurately the temperature distribution in the body resulting from RF irradiation. Temperature measurements are carried on either inaccurately, as by means of non invasive techniques; or expensively, as by means of fiberoptic sensors; or painfully, as by means of temperature probes inserted in the tissues by needles (usually 1,5 mm diameter). The new microsensors that will be developed during this project will be incorporated in needles with an external diameter of 600 mm and a length of 30-75 mm cm of length. Each microprobe will have 4-5 measurement points and an accuracy of 0,1°C. The probes will be manufactured in large scale so as to reduce their cost

Wissenschaftliches Gebiet (EuroSciVoc)

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