CORDIS provides links to public deliverables and publications of HORIZON projects.
Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .
Deliverables
A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myelin basic protein peptide 84-102. The MBP84-102 peptide is conserved between mouse and human.
The mouse spontaneously develops an MS like disease at a low incidence (2-5%) but if immunized with MBP peptide they develop the disease at 100%.
Another mouse has been produced that in addition contains the RAG deletion which leads to absence of mouse T and B cells. This mouse spontaneously developed the disease to 100%.
The disease course and pathology is reminiscent of MS and involves optic nerve, spinal cord and cerebral involvement, demyelination with plaque formation and a relapsing disease course.
Thus these two mice strains are useful as experimental models for MS.
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