CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.
Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .
Resultado final
A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myelin basic protein peptide 84-102. The MBP84-102 peptide is conserved between mouse and human.
The mouse spontaneously develops an MS like disease at a low incidence (2-5%) but if immunized with MBP peptide they develop the disease at 100%.
Another mouse has been produced that in addition contains the RAG deletion which leads to absence of mouse T and B cells. This mouse spontaneously developed the disease to 100%.
The disease course and pathology is reminiscent of MS and involves optic nerve, spinal cord and cerebral involvement, demyelination with plaque formation and a relapsing disease course.
Thus these two mice strains are useful as experimental models for MS.
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