Identification and pathological role of major genes important for development of multiple sclerosis

Informazioni relative al progetto

ID dell’accordo di sovvenzione: BMH4972522

Progetto chiuso

Data di avvio 1 Luglio 1997

Data di completamento 30 Giugno 2000

Finanziato da

• Specific research, technological development and demonstration programme in the field of biomedicine and health, 1994-1998

Costo totale

Nessun dato

Contributo UE

€ 700 000,00

Coordinato da

LUND UNIVERSITY
Sweden

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Risultati finali

A humanised mouse model for multiple sclerosis

A new mouse model has been established that is useful as a model for multiple sclerosis. The mouse contains the following genes from humans; the human class II genes DRA and DRB, the human CD4 and a human T cell receptor (TCRA and TCRB) specific for a peptide derived from myelin basic protein peptide 84-102. The MBP84-102 peptide is conserved between mouse and human. The mouse spontaneously develops an MS like disease at a low incidence (2-5%) but if immunized with MBP peptide they develop the disease at 100%. Another mouse has been produced that in addition contains the RAG deletion which leads to absence of mouse T and B cells. This mouse spontaneously developed the disease to 100%. The disease course and pathology is reminiscent of MS and involves optic nerve, spinal cord and cerebral involvement, demyelination with plaque formation and a relapsing disease course. Thus these two mice strains are useful as experimental models for MS.