Objective
Objectives and content
Manufacturers of food products, biopharmaceuticals and immobilized enzymes have a clear need for improved solid, particulate matrices which can be used for purification and immobilization of proteins (enzymes, antigens and antibodies). Today there are no materials which fulfil all the customers' demands on productivity, inertness, stability, flow properties and price.
By removing this bottleneck it would be possible to develop large-scale industrial applications for solid matrices and to open up new market niches. Immobilized enzymes are potentially very useful as biocatalysts in food processing. Similarly, immobilized antigens and antibodies have potential for the very large scale purification of biopharmaceuticals.
The objective of this project is to develop and evaluate new solid matrices which meet industry's needs. New polymerisation, surface modification and immobilization technology will be applied in the development of new matrix prototypes and a prototype process for large scale bead production. By improving the capacity, flow properties and kinetics of the matrices and by reducing the production cost it is expected that the performance/price ratio will increase by 5-10 times. Chemical leakage is expected below 10 ppb which is required for food applications.
Enzymes will be purified by chromatography using the new matrices. The enzymes will be bound to activated matrices, and the immobilized enzymes with improved performance will be characterised. The immobilized enzymes will subsequently be used for development of new processes in the area of food processing. Immobilized antigens and antibodies will be applied to the development of new processes for purification of biopharmaceuticals. Processes which involve biocatalysts are favourable compared to traditional chemical processes since they save energy, are more specific and more environmental friendly.
The consortium comprises a manufacturer of solid matrix beads (PhBio), a center of excellence in colloid, interface and polymer science (U Bristol) and a research institute specialized in surface chemistry (YKI). These partners design prototype matrices which are evaluated and used by the other partners: an enzyme manufacturer (NNAS), a food manufacturer (NESTEC) and a pharmaceutical company (ORION).
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences physical sciences condensed matter physics soft matter physics
- natural sciences chemical sciences polymer sciences
- social sciences economics and business economics production economics productivity
- natural sciences chemical sciences catalysis biocatalysis
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
751 82 Uppsala
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.