Obiettivo Numerical chromosome changes or aneuploidy make substantial contributions to human health. The objective of the project is to provide an understanding of the mechanisms by which environmental chemicals interact with the processes of chromosome segregation at mitotic and meiotic cell division and thus produce progeny cells with abnormal chromosome numbers. An understanding of chemically induced aneuploidy will allow the development, assessment and regulation of aneugenic chemicals, the determination as to whether there is a cellular threshold for such activity and provide information on the relative activity of aneugenic chemicals in male and female germ cells.The project activities involve research in a series of related areas :1) Thresholds There are theoretical reasons to assume that for at least some chemical aneugens there may be a threshold of activity. Such a threshold would allow the use of such chemicals at doses below the threshold without impairing health. Detailed dose response studies will be undertaken with selected aneugens chosen to represent different mechanisms of actions.2) Mechanisms Cellular targets whose modification may lead to induced aneuploidy will be investigated. These include : motor proteins, protein kinases, protein phosphotases and topoisomerases.3) Tissue specificity and metabolism Following the identification of the metabolic requirements for aneugenic activity in vitro, comparative studies will be performed in the tissues of rodents.4) Comparative studies in male and female germ cells Chemically induced aneuploidy will be analysed in both male and female germ cells with particular emphasis upon those chemicals which have produced discordant results between the two sexes.5) Environmental significance of aneugens Chemical aneugens for which human exposure has occurred will be evaluated in laboratory test systems.6) System development A major emphasis will be placed upon the application of fluorescence in situ hybridisation (FISH) techniques for the detection and assessment of chemical aneugens. Campo scientifico scienze naturaliscienze biologichebiochimicabiomolecoleproteinescienze naturaliscienze della terra e scienze ambientali connessescienze ambientaliinquinamentoscienze naturaliscienze biologichegeneticacromosomi Programma(i) FP3-ENV 1C - Specific research and technological development programme (EEC) in the field of the environment, 1990-1994 Argomento(i) 040204 - Risks to health and the environment from chemical substances Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITY OF WALES SWANSEA Indirizzo Singleton park SA2 8PP Swansea Regno Unito Mostra sulla mappa Contributo UE Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto GSF-RESEARCH CENTER FOR ENVIRONMENT AND HEALTH Germania Contributo UE € 0,00 Indirizzo Ingolstaedter landstrasse 1 85764 Neuherberg Mostra sulla mappa Altri finanziamenti Nessun dato Rijksuniversiteit Leiden Paesi Bassi Contributo UE € 0,00 Indirizzo 72,wassenaarseweg 2300 RA Leiden Mostra sulla mappa Altri finanziamenti Nessun dato Universität Bielefeld Germania Contributo UE € 0,00 Indirizzo 25,universitätsstraße 25 33615 Bielefeld Mostra sulla mappa Altri finanziamenti Nessun dato
