The relationship between respiratory phenotypes and mitochondrial dna mutations

Projektinformationen

ID Finanzhilfevereinbarung: FMBI950225

Startdatum 1 Mai 1996

Enddatum 30 April 1998

Finanziert unter

• Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Gesamtkosten € 0,00

EU-Beitrag Keine Daten

Koordiniert durch

University of Dundee
United Kingdom

Ziel

Although many disease-associated mitochondrial DNA (mtDNA) mutations ha been characterized. the relationship between the mutant genotype and respirators phenotype remains to be clarified in many cases. The availability of patient cells and cybrids that contain patient mitochondria. and newly developed techniques to study mitochondrial complexes, provide novel approaches to address this problem.
It is intended to test the pathogenicity of mtDNA mutations. Firstly by attempting to complement a mutant mitochondrial gene. which will entail transfecting patient cells with a code corrected version of the defective mitochondrial gene. Secondly by transfecting normal cells with a mutant mitochondrial gene. If, the synthetic genes alter the respiratory phenotype this will provide the strongest evidence to date of a causal role for mtDNA mutations in human disease. Moreover, in the longer term this strategy could offer a novel route to gene therapy of mitochondrial diseases.

Wissenschaftliches Gebiet

• medical and health sciences › medical biotechnology › genetic engineering › gene therapy
• natural sciences › biological sciences › genetics › DNA
• natural sciences › biological sciences › genetics › mutation

Programm/Programme

• FP4-TMR - Specific research and technological development programme in the field of the training and mobility of researchers, 1994-1998

Thema/Themen

• 0302 - Post-doctoral research training grants
• TL05 - Cell Biology

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

RGI - Research grants (individual fellowships)

Koordinator

University of Dundee

• EU-Beitrag: Keine Daten
• Adresse: Ninewells Hospital and Medical School ; DD1 9SY Dundee ; Vereinigtes Königreich
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Beteiligte (1)

Not available

Niederlande

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• Gesamtkosten: Keine Daten