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Contenido archivado el 2024-05-14

Role of the ci transcription factor in the hedgehog signal transduction pathway

Objetivo



Role of the Ci transcription factor in the hh signal transduction pathway Recently, the secreted hedgehog (hh) molecule has been shown to play an important role in cell-cell communication in Drosophila and in vertebrates. However, the biochemical mechanisms by which hh regulates the activities, transcriptions, or both of secondary signal transducers is poorly understood. A number of gene products including the serine/threonine kinase fused and the transcription factor cubitus interruptus (Ci) have previously been implicated as putative components of the hh signalling pathway. The objective of this proposal is to gain a more detailed understanding of the molecular basis of hh signal transduction in Drosophila. I will investigate the activity of a number of the components of the putative signalling pathway, focussing on the regulation and function of the Ci protein. These studies should in turn provide insights into the molecular basis of signalling by Hh family proteins in vertebrates.

Ámbito científico (EuroSciVoc)

Programa(s)

Tema(s)

Convocatoria de propuestas

Datos no disponibles

Régimen de financiación

RGI - Research grants (individual fellowships)

Coordinador

Imperial Cancer Research Fund
Aportación de la UE
Sin datos
Dirección
44,Lincoln's Inn Fields
WC2A 3PX London
Reino Unido
Coste total
Sin datos

Participantes (1)