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Role of the ci transcription factor in the hedgehog signal transduction pathway

Obiettivo



Role of the Ci transcription factor in the hh signal transduction pathway Recently, the secreted hedgehog (hh) molecule has been shown to play an important role in cell-cell communication in Drosophila and in vertebrates. However, the biochemical mechanisms by which hh regulates the activities, transcriptions, or both of secondary signal transducers is poorly understood. A number of gene products including the serine/threonine kinase fused and the transcription factor cubitus interruptus (Ci) have previously been implicated as putative components of the hh signalling pathway. The objective of this proposal is to gain a more detailed understanding of the molecular basis of hh signal transduction in Drosophila. I will investigate the activity of a number of the components of the putative signalling pathway, focussing on the regulation and function of the Ci protein. These studies should in turn provide insights into the molecular basis of signalling by Hh family proteins in vertebrates.

Campo scientifico (EuroSciVoc)

Programma(i)

Argomento(i)

Invito a presentare proposte

Dati non disponibili

Meccanismo di finanziamento

RGI - Research grants (individual fellowships)

Coordinatore

Imperial Cancer Research Fund
Contributo UE
Nessun dato
Indirizzo
44,Lincoln's Inn Fields
WC2A 3PX London
Regno Unito
Costo totale
Nessun dato

Partecipanti (1)