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Enantioselective synthesis of a protein tyrosine kinase inhibitor - radicicol

Ziel



The key feature of this proposal is to develop a new methodology for the synthesis of radicicol and other analogs in an efficient and selective manner. These receptor tyrosine kinase inhibitors are of great importance for pharmaceutical research and may open up alternative and better routes to study the inhibition of membrane bound protein tyrosine kinase (PTKs). Understanding the mechanisms of the inhibition in cells is an important and revelant subject to study malfunctions in the developent of cancer and other related illness. Synthesis of PTKs inhibitors provide an important entry to such studies. In this way PTK inhibition assays will be carried out to study our own compounds as possible PTK inhibitors. Further biological studies will be proposed in the light of the results of the previous assays.
Combination of our chemical techniques with other biological methods, will afford a good entry for research in Biooganic Chemistry.

Wissenschaftliches Gebiet (EuroSciVoc)

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

Daten nicht verfügbar

Finanzierungsplan

RGI - Research grants (individual fellowships)

Koordinator

Universität Karlsruhe (Technische Hochschule)
EU-Beitrag
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Adresse
12,Kaiserstrasse
76128 Karlsruhe
Deutschland
Gesamtkosten
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Beteiligte (1)