Objective
Limiting factors in pharmaceutical industry are related to organic solvent use in the production of drug systems, which generate waste streams and form toxic traces in the drug systems that often promote drug degradation. The solvent problems have increased with the development of drug delivery systems. Besides this, the applicability of several drug systems is restricted due to crystal habit and particle size distribution. Supercritical Fluid technology using compressed carbon dioxide does not have the drawback of forming contamination traces in drugs. Because of the additional degree of freedom related to the density of carbon dioxide, when either used as solvent or as anti-solvent, the technology is able to produce better designed pharmaceutical products, either simple drugs or complex encapsuled particles. Supercritical fluid technology does not create waste streams and has the advantage that the drug system is directly dry after depressurization.
WP I- Description of six drug systems - Report concerning drugs, materials, conditions, fluids and class of SC process;
WP II- Evaluation of bench scale facilities: RESS, SAS and impregnation - Manuals on the bench scale facilities, including GMP compliance - Report on single solute precipitation by RESS and SAS;
WP III- Report on impregnation of biocompatible polymers with drugs using SCF - Report on the production of drugs using RESS and SAS, including protocols for the production of specific particles;
WP IV - Process flow sheets to manufacture solvent free drug systems using SCF techniques for three selected industrial drug systems - Final report on the production of the three selected products containing:
1) Process evaluation 2) Costs comparison 3) Product comparison
WP V- Final evaluation on product and marketing aspects of the three selected drug systems.
This includes information regarding:
- the drug release profile;
- the required amount of drug;
- therapy and administration;
- marketing prospects.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs
- natural sciences chemical sciences polymer sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
94204 IVRY-SUR-SEINE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.