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Bcg vaccination and childhood morbidity and mortality : interventions with possible implications for immunisation policy in developing countries

Objective

It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

STATENS SERUM INSTITUT
Address
5,Artillerivej 5
2300 Koepenhagen
Denmark

Participants (4)

LABORATORIO NACIONAL DE SAUDE PUBLICO
Guinea-Bissau
Address
Ministerio De Saude Publica
Bissau
LEIDEN UNIVERSITY
Netherlands
Address
Albinusdreef 2
2300 RC Leiden
MEDICAL RESEARCH COUNCIL
The Gambia
Address
Faraja
Banjul
PROJECTO DE SAUDE DE BANDIM
Guinea-Bissau
Address

Bissau