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Content archived on 2024-05-21

Bcg vaccination and childhood morbidity and mortality : interventions with possible implications for immunisation policy in developing countries

Objective

It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined.

Topic(s)

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Call for proposal

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Coordinator

STATENS SERUM INSTITUT
EU contribution
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Address
5,ARTILLERIVEJ 5
2300 KOEPENHAGEN
Denmark

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Participants (4)