It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined.
Funding SchemeCSC - Cost-sharing contracts
2300 RC Leiden