Bcg vaccination and childhood morbidity and mortality : interventions with possible implications for immunisation policy in developing countries

Objective

It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined.

Programme(s)

• FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002"

Funding Scheme

Coordinator

Participants (4)