Obiettivo It is proposed to examined the non-specific effects of BCG vaccination through three randomised trials with possible implications for immunisation policies in developing countries. It will be examined whether revaccination with BCG reduces mortality with 30%, whether BCG vaccination at birth of low birth weight children is associated with better BCG coverage and 25% lower mortality, and whether vitamin A supplementation simultaneously with BCG vaccination is associated with a 30% reduction in infant mortality. None of these measures are standard in the current immunisation programmes in developing countries; however, observational studies suggest that BCG vaccination may have non-specific beneficial effects. The impact on severe morbidity and hospitalisations, in particular from malaria, will also be examined through surveillance at the paediatric department. The possible immunological basis for non-specific effects will be examined. Campo scientifico medical and health scienceshealth sciencesinfectious diseasesmalariasocial sciencessociologydemographymortalitymedical and health sciencesbasic medicineimmunologyimmunisation Programma(i) FP5-INCO 2 - Programme for research, technological development and demonstration on "Confirming the international role of Community research,1998-2002" Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore STATENS SERUM INSTITUT Contributo UE Nessun dato Indirizzo 5,ARTILLERIVEJ 5 2300 KOEPENHAGEN Danimarca Mostra sulla mappa Costo totale Nessun dato Partecipanti (4) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto LABORATORIO NACIONAL DE SAUDE PUBLICO Guinea-Bissau Contributo UE Nessun dato Indirizzo Ministerio de Saude Publica BISSAU Mostra sulla mappa Costo totale Nessun dato LEIDEN UNIVERSITY Paesi Bassi Contributo UE Nessun dato Indirizzo Albinusdreef 2 2300 RC LEIDEN Mostra sulla mappa Costo totale Nessun dato MEDICAL RESEARCH COUNCIL Gambia Contributo UE Nessun dato Indirizzo Faraja BANJUL Mostra sulla mappa Costo totale Nessun dato PROJECTO DE SAUDE DE BANDIM Guinea-Bissau Contributo UE Nessun dato Indirizzo BISSAU Mostra sulla mappa Costo totale Nessun dato