Exploitable results
The study was devoted to aspects of biological electron transfer and energy conservation, in particular the question of the possible role of transmembrane ion gradients of sodium ions or chloride ions in replacing the role of the proton in providing an ionmotive force linking electron transfer to ATP synthesis.
Work in the London laboratory was focused on screening of a wide range of chemicals that might act as inhibitors of ubiquinone binding sites in respiratory NADH dehydrogenases. The work provides a step towards the provision of a set of specific inhibitors that can be used to categorise and quantitate the numbers and levels of NADH dehydrogenases in respiratory membranes. Further work resolved the numbers and levels of various NADH-ubiquinone oxidoreductases in a range of biological membrane samples.
In Germany and Moscow, studies were made of halorodopsin-driven energetics in Natronobacterium pharaonis, an archaeal species from the soda lakes of the Wadi Natrun of upper Egypt and it was proposed that the photophosphorylation is coupled to the halorhodopsin-generated membrane potential by a chloride ion gradient, utilizing a chloride-dependent ATP synthase.
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