Carotid intima media thickness (imt) and imt-progression as predictors of vascular events in a high risk population (improve)

Objetivo

The study aims to evaluate:
(a) the association between 15 month IMT-progression of carotid artery and the rate of vascular events (from the 15th to the 36th month of follow up) in subjects at high risk of atherosclerosis and
(b) the association between cross-sectional carotid arteries IMT and the rate of vascular events. The effect of gene polymorphisms, lipid peroxidation, socio-economic and psychological variables on the same ultrasonographic end points will be also assessed. In addition, the study will:
(a)standardize at EU level an ultrasound scan and reading protocol to be used in future clinical trials;
(b)compare the genetic and ultrasonic characteristics of patients from north and south Europe;
(c) assess the impact of an early detection of atherosclerotic disease on the patients’ quality of life and
(d) its economic consequences.
Data will be analysed with conventional statistic vs. an innovative approach based on artificial neural networks.

Ámbito científico

• ciencias médicas y de la salud › medicina clínica › cardiología › enfermedad cardiovascular › arteriosclerosis
• ciencias naturales › ciencias biológicas › bioquímica › biomoléculas › lípidos
• ciencias naturales › ciencias físicas › acústica › ultrasonido
• ciencias naturales › informática y ciencias de la información › inteligencia artificial › inteligencia computacional

Programa(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Tema(s)

• 1.1.1.-7. - Chronic and degenerative diseases, cancer, diabetes, cardivascular diseases and rare diseases

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

THE UNIVERSITY OF MILANO

Dirección

Via Balzaretti 9
20133 Milano
Italia

Participantes (10)

ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS

Francia

Dirección

Boulevard De L'hopital 47-83
75651 Paris

BRACCO IMAGING S.P.A

Italia

Dirección

Via Egidio Folli, 50
20134 Milano

CENTRO CARDIOLOGICO MONZINO SPA

Italia

Dirección

Via Filodrammatici, 10
20122 Milano

CFCONSULTING FINAZIAMENTI UNIONE EUROPEA S.R.L

Italia

Dirección

Via Giuseppe Mussi, 1
20154 Milano

FOUNDATION FOR RESEARCH IN HEALTH EXERCISE AND NUTRITION

Finlandia

Dirección

Haapaniementie 16
Kuopio

Enlaces

KAROLINSKA INSTITUTE

Suecia

Dirección

Karolinska Hospital
17116 Stockholm

UNIVERSITA DEGLI STUDI DI PERUGIA

Italia

Dirección

Via Brunamonti, 51
06122 Perugia

UNIVERSITY COLLEGE LONDON

United Kingdom

Dirección

University Street 5
WC1E 6JJ London

UNIVERSITY OF GRONINGEN

Países Bajos

Dirección

Hanzeplein 1
9700 RB Groningen

UNIVERSITY OF KUOPIO

Finlandia

Dirección

Harjulantie 1 B
70211 Kuopio