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Development of novel gene expression and genome modification strategies

Objective

Gene transfer protocols used for bio molecule productions and therapeutic strategies suffer from lack of control of the fate of the foreign DNA within the host genome. The efficient expression of the transferred DNA relies on the site of its integration, on the presence of cis DNA regulatory elements and on nuclear proteins which participate in the formation of the chromatin at the transgeniclocus. This proposal aims at studying all these contributing factors in order to develop methods which can target the foreign DNA at preselected, precharacterised sites in the genome and guarantee stable and/or regulatable expression of the transferred genes, without interrupting or activating endogenous neighbouring gene loci.

Funding Scheme

CSC - Cost-sharing contracts

Coordinator

MRC National Institute for Medical Research
Address
The Ridgeway Mill Hil
NW7 1AA London
United Kingdom

Participants (7)

ERASMUS UNIVERSITEIT ROTTERDAM
Netherlands
Address
Dr. Molewaterplein 50
3000 DR Rotterdam
FOUNDATION OF RESEARCH AND TECHNOLOGY - HELLAS
Greece
Address
Vassilika Vouton
71110 Iraklion
GBF - NATIONAL CENTRE FOR BIOTECHNOLOGY
Germany
Address
1,Mascheroder Weg 1
38124 Braunschweig
IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE
United Kingdom
Address
Du Cane Road
W12 0NN London
ROSLIN INSTITUTE (EDINBURGH)
United Kingdom
Address

EH25 9PS Roslin, Midlothian
RUPRECHT-KARLS-UNIVERSITAET HEIDELBERG
Germany
Address
Im Neuenheimer Feld 282
69120 Heidelberg
UNIVERSITÀ DEGLI STUDI DI ROMA TOR VERGATA
Italy
Address
135,Via Di Tor Vergata 135
00133 Roma