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Contenido archivado el 2024-05-27

Development of novel gene expression and genome modification strategies

Objetivo

Gene transfer protocols used for bio molecule productions and therapeutic strategies suffer from lack of control of the fate of the foreign DNA within the host genome. The efficient expression of the transferred DNA relies on the site of its integration, on the presence of cis DNA regulatory elements and on nuclear proteins which participate in the formation of the chromatin at the transgeniclocus. This proposal aims at studying all these contributing factors in order to develop methods which can target the foreign DNA at preselected, precharacterised sites in the genome and guarantee stable and/or regulatable expression of the transferred genes, without interrupting or activating endogenous neighbouring gene loci.

Ámbito científico

CORDIS clasifica los proyectos con EuroSciVoc, una taxonomía plurilingüe de ámbitos científicos, mediante un proceso semiautomático basado en técnicas de procesamiento del lenguaje natural.

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

MRC National Institute for Medical Research
Aportación de la UE
Sin datos
Dirección
The Ridgeway Mill Hil
NW7 1AA London
Reino Unido

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Coste total
Sin datos

Participantes (7)