Study of the adhesive interaction between human and pig cells via daf/cd97. significance in xenotransplantation

Ziel

In xenotransplantation, adhesion of pig-to-human cells may play an important role in the rejection of porcine xenograft issues. Human decay accelerating factor (DAF or CD55) is an important regulator of the complement activation. Transgenic pigs expressing human DAF are being bred in the expectation that organs from these pigs will be better protected from hyperacute rejection, a consequence of the activation of complement. Recently, DAF have been identified as a high affinity ligand for the CD97 molecule, which is expressed upon activation of many !eucocytes. Hence, expression of DAF in pig organs, although abrogating hyperacute rejection, might theoretically predispose to develop.

Programm/Programme

FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thema/Themen

1.1.1.-3. - Key action The "Cell factory"

Aufforderung zur Vorschlagseinreichung

Data not available

Finanzierungsplan

RGI - Research grants (individual fellowships)

Koordinator

UNIVERSIDAD DE CORDOBA

EU-Beitrag

Keine Daten

Adresse

S/N,Avenida Menéndez Pidal S/N
14080 CORDOBA
Spanien

Gesamtkosten