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DNA replication and biotechnological applications

Objetivo

DNA replication is a key process involved in cell division of all living creatures. Based on the structural and functional homology between archaic andeukaryotes, this project proposes to co-ordinate efforts of one SME and seven laboratories from five European countries on the characterisation of DNAreplication components, DNA Polyrnerases, accessory proteins, both in archaic and Human. Each step of DNA replication will be investigated, initiation, elongation and processing of the lagging strand in order
(I) to understand the basic mechanisms at each level,
(ii) to isolate novel proteins and enzymes and
(iii) to increase the probability of finding new products and key residues. Two fields of application are concerned:
molecular biology products in vitro amplification and health with novel DNA replication inhibitors

Convocatoria de propuestas

Data not available

Régimen de financiación

CSC - Cost-sharing contracts

Coordinador

IFREMER - INSTITUT FRANÇAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER
Dirección
Rue Jean-jacques Rousseau 155, Technopolis 40
92138 Issy Les Moulineaux
Francia
 

Participantes (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Francia
Dirección
Rue Michel Ange 3
75794 Paris
KAROLINSKA INSTITUTE
Suecia
Dirección
6,Blickagangen 6
141 57 Huddinge
 
NATIONAL RESEARCH COUNCIL OF ITALY
Italia
Dirección
Piazzale Aldo Moro 7
00185 Roma
 
UNIVERSITE DE PARIS-SUD XI
Francia
Dirección
Rue Georges Clemenceau 15
91405 Orsay
 
UNIVERSITY OF ZURICH
Suiza
Dirección
71,Raemistrasse 71
CH-8091 Zurich