DNA replication and biotechnological applications

Objectif

DNA replication is a key process involved in cell division of all living creatures. Based on the structural and functional homology between archaic andeukaryotes, this project proposes to co-ordinate efforts of one SME and seven laboratories from five European countries on the characterisation of DNAreplication components, DNA Polyrnerases, accessory proteins, both in archaic and Human. Each step of DNA replication will be investigated, initiation, elongation and processing of the lagging strand in order
(I) to understand the basic mechanisms at each level,
(ii) to isolate novel proteins and enzymes and
(iii) to increase the probability of finding new products and key residues. Two fields of application are concerned:
molecular biology products in vitro amplification and health with novel DNA replication inhibitors

Champ scientifique

• sciences naturelles › sciences biologiques › génétique › ADN
• sciences naturelles › sciences biologiques › biochimie › biomolécule › protéines › enzyme
• sciences naturelles › sciences biologiques › biologie moléculaire

Programme(s)

• FP5-LIFE QUALITY - Specific Programme for research, technological development and demonstration on "Quality of life and management of living resources", 1998-2002

Thème(s)

• 1.1.1.-3. - Key action The "Cell factory"

Appel à propositions

Data not available

Régime de financement

CSC - Cost-sharing contracts

Coordinateur

IFREMER - INSTITUT FRANÇAIS DE RECHERCHE POUR L'EXPLOITATION DE LA MER

Adresse

Rue Jean-jacques Rousseau 155, Technopolis 40
92138 Issy Les Moulineaux
France

Participants (5)

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

France

Adresse

Rue Michel Ange 3
75794 Paris

Liens

KAROLINSKA INSTITUTE

Suède

Adresse

6,blickagangen 6
141 57 Huddinge

NATIONAL RESEARCH COUNCIL OF ITALY

Italie

Adresse

Piazzale Aldo Moro 7
00185 Roma

UNIVERSITE DE PARIS-SUD XI

France

Adresse

Rue Georges Clemenceau 15
91405 Orsay

UNIVERSITY OF ZURICH

Suisse

Adresse

71,raemistrasse 71
CH-8091 Zurich