Obiettivo The main objectIve of the present project is the understanding of the developmental processes that take place during the life cycle of E. granulosus. The knowledge of the basic processes involved in the parasite's - development could be important to understand the bases of the specificity of the host-parasite adaptation and could provide new tools to control hydatid disease. From a basic point of view, flatworms are particularly Interesting in Develpmental Biology since they are the first organisms With bilateral symmetry and an antero posterior identity, and they exhibit exceptional developmental behaviours (sexual and asexual reproductive phases, ability of intermediary stages to develop towards larval or adult forms, regeneration Processes in free-living organisms, among others). During the first phase of this project, different genomic and CDNA libraries were constructed. Several genes were isolated from these libraries and they were partially sequenced (genes encoding cytoskeletal proteins, a gene encoding thymidylate synthase, several homeobox-containing genes, ribosomal RNA genes and different repetitive sequences). In the second phase, the principal aim is the study of the expression of these genes, in particular looking for stage-specific expression during the parasite's life-cycle. The establishment of rellable specific expression systems appears as an essential requirement. At the same time, particular emphasis will be laid on the search of hormone-like substances or hormone receptors encoded by the parasite. Finally, a complementary objective, related to the construction of live anti-helminthic vaccines, is focused in the improvement of the expression of plathyhelmint genes in Salmonella. Campo scientifico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccinesnatural sciencesbiological sciencesgeneticsRNA Programma(i) FP3-STD 3 - Specific research and technological development programme (EEC) in the field of the life sciences and technologies for developing countries, 1990-1994 Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore Universidad de la República Contributo UE Nessun dato Indirizzo 1674,Tristan Narvaja Montevideo Uruguay Mostra sulla mappa Costo totale Nessun dato Partecipanti (3) Classifica in ordine alfabetico Classifica per Contributo UE Espandi tutto Riduci tutto THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE Regno Unito Contributo UE Nessun dato Indirizzo Trinity Lane, The Old Schools, CB2 1TN CAMBRIDGE Mostra sulla mappa Costo totale Nessun dato UNIVERSITE DE PARIS-SUD XI Francia Contributo UE Nessun dato Indirizzo Rue Georges Clemenceau 15, BFtiment 400 91405 GOMETZ LA VILLE Mostra sulla mappa Costo totale Nessun dato Universidade Federal do Rio Grande doSul Brasile Contributo UE Nessun dato Indirizzo 9500,Avenida Bento Gonçalves 91501 Porto Alegre Mostra sulla mappa Costo totale Nessun dato