Objective
This study will investigate different hypotheses for the mechanisms underlying excess delayed mortality after measles or high titre measles Vaccines. Morbidity will be monitored after mild measles (among children recruited through community-based surveillance) or complicated measles (recruited at hospital), and compared to controls (a cohort of healthy children and a cohort of children hospitalised with other illnesses). 110 children will be recruited in each group, and will be examined twice weekly in the first 6 weeks then weekly until 8 months after recruitment. To investigate the hypothesis that measles virus causes a prolonged bias to a type 2 helper T cell response (which is predicted to increase the antibody response to infectious agents), the response to the hepatitis B vaccine series commenced 6 weeks after recruitment will be compared between cases and controls. In each analysis, age, sex, socioeconomic status, nutritional status and micronutrient levels will be assessed as possible confounders.
On a subsample of subjects aged 6-11 months, (n=25 per group), the study will measure the lymphoproliferative response to stimulation with measles virus and measles virus purified membrane proteins, cytokine profiles, and changes in surface molecules, particularly those involved in the MV receptor complex, on sub-populations of peripheral blood mononuclear cells (PBMCS). Two groups of measles vaccines (n=25 per group) will also be studied, one group receiving two doses of standard titre measles vaccines at ages 6 and 9 months, the other a single dose at 9 months, to allow comparison of the effects of wild versus vaccine virus on cellular function. The presence of measles virus in PBMC samples and subpopulations in children with acute measles will be compared to Vaccinees at different time points following exposure. These studies will help to understand the basis for immune suppression after measles, to determine the extent of immunosuppression after measles vaccination, and to raise hypotheses for the mechanism of differences in persistence of immunity after measles or measles vaccination. This information will be invaluable in the development and evaluation of novel measles vaccines.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- natural sciences biological sciences microbiology virology
- medical and health sciences health sciences infectious diseases
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WC1E 7HT London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.