Objective Despite significant achievements in the field of regenerative medicine and the enormous potential for engineered tissue products, significant hurdles have prevented cellular therapies from gaining wide-spread clinical adoption. Manufacturing related issues have been proposed as key challenges to be addressed for the translation of regenerative therapies to the clinic and the successful commercialization of engineered products. Similar to other biotechnology sectors (e.g. vaccines or recombinant protein production), bioreactor systems could play a central role in establishing engineered tissues in the clinic. In fact, by automating and streamlining manufacturing processes, they would allow to improve product reproducibility, safety, standardization and possibly reach cost-effectiveness. This project aims at the development, pre-clinical and clinical testing of a sensor-based bioreactor system for the production of functional, autologous engineered grafts with reproducible properties. The bioreactor-based manufacturing paradigm will be addressed in the specific context of cartilage repair. Innovative features of the proposed tissue engineering strategy will include: (i) an automated and controlled production system, (ii) bioreactor conforming to regulatory guidelines, (iii) simplified, streamlined, and scalable tissue engineering process, (iv) on-line monitoring of culture/quality parameters, and (v) data management systems for traceability. To achieve these goals, BIO-COMET brings together internationally renowned leaders in the field of regenerative medicine, from academic, clinical and industrial research institutions. Successful implementation of the project will be instrumental to extend use of bioreactor-based platforms beyond cartilage tissue engineering, with the ultimate goal to facilitate broad utilization and commercialization of cell-based grafts as therapeutic solutions. Fields of science engineering and technologymechanical engineeringmanufacturing engineeringengineering and technologyenvironmental biotechnologybioremediationbioreactorsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.4-2 - Tools, technologies and devices for application in regenerative medicine Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITATSSPITAL BASEL EU contribution € 1 269 000,00 Address HEBELSTRASSE 32 4031 Basel Switzerland See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Ivan Martin (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (8) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF BRISTOL United Kingdom EU contribution € 559 892,60 Address BEACON HOUSE QUEENS ROAD BS8 1QU Bristol See on map Region South West (England) Gloucestershire, Wiltshire and Bristol/Bath area Bristol, City of Activity type Higher or Secondary Education Establishments Administrative Contact Maria Davies (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SVEUCILISTE U ZAGREBU Croatia EU contribution € 614 729,60 Address TRG REPUBLIKE HRVATSKE 14 10000 Zagreb See on map Region Hrvatska Grad Zagreb Grad Zagreb Activity type Higher or Secondary Education Establishments Administrative Contact Hrvoje Matakovic (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO ORTOPEDICO RIZZOLI Italy EU contribution € 620 500,00 Address VIA DI BARBIANO 1/10 40136 Bologna See on map Region Nord-Est Emilia-Romagna Bologna Activity type Research Organisations Administrative Contact Andrea Rizzi (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data CELLEC BIOTEK AG Switzerland EU contribution € 885 000,00 Address VOGESENSTRASSE 135 4056 BASEL See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Montefiori Michele (Dr.) Links Contact the organisation Opens in new window Total cost No data PRESENS PRECISION SENSING GMBH Germany EU contribution € 568 200,00 Address AM BIOPARK 11 93053 Regensburg See on map Region Bayern Oberpfalz Regensburg, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Christian Krause (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data HOLOSTEM TERAPIE AVANZATE SRL Italy EU contribution € 429 500,40 Address VIA GLAUCO GOTTARDI 100 41125 Modena See on map Region Nord-Est Emilia-Romagna Modena Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Graziella Pellegrini (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data OCTANE BIOTECH INC Canada EU contribution € 641 268,00 Address CATARAQUI WOODS DRIVE 640 K7P 2Y5 KINGSTON See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Timothy Smith (Dr.) Links Contact the organisation Opens in new window Total cost No data FIN-CERAMICA FAENZA SPA Italy EU contribution € 406 276,50 Address Via Granarolo 177/3 48018 Faenza See on map Region Nord-Est Emilia-Romagna Ravenna Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Elisa Figallo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data