Objective
"This project will develop novel, bio-inspired routes to the synthesis of porous inorganic nanoparticles with sponge-like internal structures, using nanostructured polymer capsules as templates. The application of these structures in targeted drug delivery and controlled release will then be investigated. Biominerals provide a unique inspiration for the design and synthesis of new materials. While showing remarkable structures and properties, these amazing materials form in aqueous environments under ambient conditions and organic molecules – either as soluble additives or insoluble matrices – are used to control crystal growth. We will here employ a bio-inspired strategy to generate porous calcium carbonate and calcium phosphate nanoparticles with sponge-like structures. A novel class of polymer capsules with bicontinuous internal structures, which are formed by the self-assembly of comb-like block copolymers in water will be used as templates. This system will also provide a unique opportunity for studying the effect of confinement on crystal nucleation and growth. Crystallisation in confinement is widespread in Nature, the environment and technology, and the research will therefore impact on fundamental research and technology across many disciplines. The synthesised porous nanoparticles will then be used to build targeted drug delivery systems (DDSs) by encapsulating anti-cancer drugs for the treatment of bone cancer. While mesoporous silica nanoparticles have been investigated quite extensively, little work has to-date been performed on alternative nanoporous crystalline inorganic nanoparticles. As compared with mesoporous silica, the calcium phosphate and calcium carbonate nanoparticles will show superior biocompatibility and biodegradation, and will also offer acid-responsive solubility and therefore will give the pH-responsive release of the encapsulated drugs from the drug delivery system in the acidic environment of tumors."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences chemical sciences inorganic chemistry inorganic compounds
- natural sciences chemical sciences inorganic chemistry alkaline earth metals
- natural sciences chemical sciences polymer sciences
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IIF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
LS2 9JT Leeds
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.