Objectif Currently cervical histology is the gold standard procedure in the field. However, there is a need for alternative approaches and specific biomarkers to aid objective CIN lesion grading and to identify true high grade cervical disease, especially in the advent of primary HPV screening and widespread HPV vaccination.Panel of mRNA markers has been developed using systems biology and datamining tools and has demonstrated high specificity [93%] and sensitivity [88%] for detecting CIN 2-3 lesions. Clinical data supports its application as a cervical cancer grading biomarker as well. Our goal is to ascertain the utility of this novel panel and extend it using systems biology approaches with experimentally and computationally derived proteomic biomarkers in cervical pre cancer and cancer disease, for more accurate diagnosis of CIN disease. Toward that goal we establish a general framework for validation of proteomic biomarkers. This will be achieved by combining advanced technologies in a robust and time-effective way, including DNA array to protein array copying, Human Combinatorial Antibody Library of phage display and iRIfS, imaging Reflectometric Interference Spectroscopy technology. Systems biology approached would focus on both the existing and new markers and will use this framework rapid validation. Systems biology exploration of some specific pathways is justified by our previous data, that the CIN1/CIN2+ discrimination could be related to some given pathways.The proposed approach potentially reduce costs of cervical clinical studies providing a reliable, quantitative, multi-content diagnostic approaches and results in reducing the number of colposcopic events. Cytology specimens will be of greater clinical utility and will result in earlier detection of disease. Molecular characterization of CIN lesions provides a basis for re-definition of histological categories. Champ scientifique natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinephysiologycytologymedical and health sciencesclinical medicineoncologycervical cancermedical and health scienceshealth sciencesinfectious diseasesDNA virusesnatural sciencesbiological scienceshistology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Thème(s) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Appel à propositions FP7-HEALTH-2012-INNOVATION-1 Voir d’autres projets de cet appel Régime de financement CP-FP - Small or medium-scale focused research project Coordinateur THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Contribution de l’UE € 442 084,00 Adresse COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Irlande Voir sur la carte Région Ireland Eastern and Midland Dublin Type d’activité Higher or Secondary Education Establishments Contact administratif Deidre Savage (Ms.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Participants (4) Trier par ordre alphabétique Trier par contribution de l’UE Tout développer Tout réduire ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Allemagne Contribution de l’UE € 454 440,00 Adresse FAHNENBERGPLATZ 79098 Freiburg Voir sur la carte Région Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Type d’activité Higher or Secondary Education Establishments Contact administratif Melanie Baumann Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée Cellcall Kft. Hongrie Contribution de l’UE € 1 033 460,00 Adresse ROPPENTYU UTCA 48 1139 BUDAPEST Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Miklós Nyíri (Mr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée BIAMETRICS GMBH Allemagne Contribution de l’UE € 438 900,00 Adresse AUF DER MORGENSTELLE 18 72076 TUBINGEN Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Guenther Proll (Dr.) Liens Contacter l’organisation Opens in new window Site web Opens in new window Coût total Aucune donnée GENOID MOLEKULARBIOLOGIAI KUTATO, GYARTO ES EGESZSEGUGYI SZOLGALATO KFT Participation terminée Hongrie Contribution de l’UE Aucune donnée Adresse ROPPENTYU UTCA 48 1139 BUDAPEST Voir sur la carte Type d’activité Private for-profit entities (excluding Higher or Secondary Education Establishments) Contact administratif Csaba Jeney (Dr.) Liens Contacter l’organisation Opens in new window Coût total Aucune donnée