Objetivo Currently cervical histology is the gold standard procedure in the field. However, there is a need for alternative approaches and specific biomarkers to aid objective CIN lesion grading and to identify true high grade cervical disease, especially in the advent of primary HPV screening and widespread HPV vaccination.Panel of mRNA markers has been developed using systems biology and datamining tools and has demonstrated high specificity [93%] and sensitivity [88%] for detecting CIN 2-3 lesions. Clinical data supports its application as a cervical cancer grading biomarker as well. Our goal is to ascertain the utility of this novel panel and extend it using systems biology approaches with experimentally and computationally derived proteomic biomarkers in cervical pre cancer and cancer disease, for more accurate diagnosis of CIN disease. Toward that goal we establish a general framework for validation of proteomic biomarkers. This will be achieved by combining advanced technologies in a robust and time-effective way, including DNA array to protein array copying, Human Combinatorial Antibody Library of phage display and iRIfS, imaging Reflectometric Interference Spectroscopy technology. Systems biology approached would focus on both the existing and new markers and will use this framework rapid validation. Systems biology exploration of some specific pathways is justified by our previous data, that the CIN1/CIN2+ discrimination could be related to some given pathways.The proposed approach potentially reduce costs of cervical clinical studies providing a reliable, quantitative, multi-content diagnostic approaches and results in reducing the number of colposcopic events. Cytology specimens will be of greater clinical utility and will result in earlier detection of disease. Molecular characterization of CIN lesions provides a basis for re-definition of histological categories. Ámbito científico natural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsmedical and health sciencesbasic medicinephysiologycytologymedical and health sciencesclinical medicineoncologycervical cancermedical and health scienceshealth sciencesinfectious diseasesDNA virusesnatural sciencesbiological scienceshistology Programa(s) FP7-HEALTH - Specific Programme "Cooperation": Health Tema(s) HEALTH.2012.2.1.2-1 - Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs Convocatoria de propuestas FP7-HEALTH-2012-INNOVATION-1 Consulte otros proyectos de esta convocatoria Régimen de financiación CP-FP - Small or medium-scale focused research project Coordinador THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN Aportación de la UE € 442 084,00 Dirección COLLEGE GREEN TRINITY COLLEGE D02 CX56 DUBLIN 2 Irlanda Ver en el mapa Región Ireland Eastern and Midland Dublin Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Deidre Savage (Ms.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Participantes (4) Ordenar alfabéticamente Ordenar por aportación de la UE Ampliar todo Contraer todo ALBERT-LUDWIGS-UNIVERSITAET FREIBURG Alemania Aportación de la UE € 454 440,00 Dirección FAHNENBERGPLATZ 79098 Freiburg Ver en el mapa Región Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis Tipo de actividad Higher or Secondary Education Establishments Contacto administrativo Melanie Baumann Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos Cellcall Kft. Hungría Aportación de la UE € 1 033 460,00 Dirección ROPPENTYU UTCA 48 1139 BUDAPEST Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Miklós Nyíri (Mr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos BIAMETRICS GMBH Alemania Aportación de la UE € 438 900,00 Dirección AUF DER MORGENSTELLE 18 72076 TUBINGEN Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Guenther Proll (Dr.) Enlaces Contactar con la organización Opens in new window Sitio web Opens in new window Coste total Sin datos GENOID MOLEKULARBIOLOGIAI KUTATO, GYARTO ES EGESZSEGUGYI SZOLGALATO KFT La participación finalizó Hungría Aportación de la UE Sin datos Dirección ROPPENTYU UTCA 48 1139 BUDAPEST Ver en el mapa Tipo de actividad Private for-profit entities (excluding Higher or Secondary Education Establishments) Contacto administrativo Csaba Jeney (Dr.) Enlaces Contactar con la organización Opens in new window Coste total Sin datos