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Metagenomics in Cardiometabolic Diseases

Ziel

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ageing populations and costly treatments. Therapies require novel integrated approaches taking into account CMD natural evolution.

METACARDIS associates European leaders in metagenomics, who have been successful in establishing the structure of the human microbiome as part of the EU FP7 MetaHIT consortium, clinical and fundamental researchers, SME, patients associations and food companies to improve the understanding of pathophysiological mechanisms, prognosis and diagnosis of CMD.

We will use next-generation sequencing technologies and high throughput metabolomic platforms to identify gut microbiota- and metabolomic-derived biomarkers and targets associated with CMD risks. The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation tools to complex datasets combining clinical information, environmental patterns and gut microbiome, metabolome and transcriptome data is a central integrating component in the research, which will be driven by world leaders in metagenomic and functional genomic data analysis. These studies will identify novel molecular targets, biomarkers and predictors of CMD progression, paving the way for personalized medicine in CMD.

Aufforderung zur Vorschlagseinreichung

FP7-HEALTH-2012-INNOVATION-1
Andere Projekte für diesen Aufruf anzeigen

Finanzierungsplan

CP-IP - Large-scale integrating project

Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Adresse
Rue De Tolbiac 101
75654 Paris
Frankreich
Aktivitätstyp
Research Organisations
EU-Beitrag
€ 2 512 788
Kontakt Verwaltung
Akouavi Ekoue (Ms.)

Beteiligte (15)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Frankreich
EU-Beitrag
€ 2 649 374
Adresse
147 Rue De L'universite
75007 Paris Cedex 07
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Lucie Bourse (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
EU-Beitrag
€ 1 151 649,80
Adresse
South Kensington Campus Exhibition Road
SW7 2AZ London
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Tatjana Palalic (Ms.)
KOBENHAVNS UNIVERSITET
Dänemark
EU-Beitrag
€ 900 050
Adresse
Norregade 10
1165 Kobenhavn
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Kristoffersen Ivan (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Deutschland
EU-Beitrag
€ 911 396
Adresse
Meyerhofstrasse 1
69117 Heidelberg
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Phil Irving (Dr.)
GOETEBORGS UNIVERSITET
Schweden
EU-Beitrag
€ 699 999
Adresse
Vasaparken
405 30 Goeteborg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Ellen Rydberg (Dr.)
VIB VZW
Belgien
EU-Beitrag
€ 551 590
Adresse
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Rik Audenaert (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Frankreich
EU-Beitrag
€ 540 000
Adresse
3 Avenue Victoria
75000 Paris
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Alix Pillot (Ms.)
UNIVERSITAET LEIPZIG
Deutschland
EU-Beitrag
€ 715 480
Adresse
Ritterstrasse 26
04109 Leipzig
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Michael Stumvoll (Prof.)
DANONE RESEARCH SAS
Frankreich
EU-Beitrag
€ 159 400
Adresse
Route Departementale 128
91767 Palaiseau
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Nicolas Gausseres (Mr.)
CARGILL HAUBOURDIN SAS

Beteiligung beendet

Frankreich
EU-Beitrag
€ 19 000
Adresse
Rue Du Marechal Joffre 7
59482 Haubourdin
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Douwina Bosscher (Dr.)
CHALMERS TEKNISKA HOEGSKOLA AB
Schweden
EU-Beitrag
€ 550 000
Adresse
-
41296 Goeteborg
Aktivitätstyp
Higher or Secondary Education Establishments
Kontakt Verwaltung
Karin Ryrberg (Ms.)
INSERM TRANSFERT SA
Frankreich
EU-Beitrag
€ 496 328
Adresse
Rue Watt 7
75013 Paris
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Catherine Clusel (Dr.)
BIOBYTE SOLUTIONS GMBH
Deutschland
EU-Beitrag
€ 142 937,20
Adresse
Bothestrasse 142
69126 Heidelberg
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Ivica Letunic (Dr.)
INST CARDIOMETABOLISME NUTRITION ICAN
Frankreich
Adresse
Boulevard De L'hopital 47-83
75013 Paris
Aktivitätstyp
Research Organisations
Kontakt Verwaltung
Marie-Laure Henrotte (Mrs.)
CARGILL R&D CENTRE EUROPE
Belgien
Adresse
Havenstraat 84
1800 Vilvoorde
Aktivitätstyp
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Kontakt Verwaltung
Doreen Vynck (Mrs.)