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Metagenomics in Cardiometabolic Diseases

Obiettivo

METACARDIS applies a systems medicine multilevel approach to identify biological relationships between gut microbiota, assessed by metagenomics, and host genome expression regulation, which will improve understanding and innovative care of cardiometabolic diseases (CMD) and their comorbidities. CMD comprise metabolic (obesity, diabetes) and heart diseases characterized by a chronic evolution in ageing populations and costly treatments. Therapies require novel integrated approaches taking into account CMD natural evolution.

METACARDIS associates European leaders in metagenomics, who have been successful in establishing the structure of the human microbiome as part of the EU FP7 MetaHIT consortium, clinical and fundamental researchers, SME, patients associations and food companies to improve the understanding of pathophysiological mechanisms, prognosis and diagnosis of CMD.

We will use next-generation sequencing technologies and high throughput metabolomic platforms to identify gut microbiota- and metabolomic-derived biomarkers and targets associated with CMD risks. The pathophysiological role of these markers will be tested in both preclinical models and replication cohorts allowing the study of CMD progression in patients collected in three European clinical centres of excellence. Their impact on host gene transcription will be characterised in patients selected for typical features of CMD evolution. Application of computational models and visualisation tools to complex datasets combining clinical information, environmental patterns and gut microbiome, metabolome and transcriptome data is a central integrating component in the research, which will be driven by world leaders in metagenomic and functional genomic data analysis. These studies will identify novel molecular targets, biomarkers and predictors of CMD progression, paving the way for personalized medicine in CMD.

Invito a presentare proposte

FP7-HEALTH-2012-INNOVATION-1
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Coordinatore

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Indirizzo
Rue De Tolbiac 101
75654 Paris
Francia

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Tipo di attività
Research Organisations
Contatto amministrativo
Akouavi Ekoue (Ms.)
Contributo UE
€ 2 562 788

Partecipanti (15)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Francia
Contributo UE
€ 2 649 374
Indirizzo
147 Rue De L'universite
75007 Paris Cedex 07

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Research Organisations
Contatto amministrativo
Lucie Bourse (Ms.)
IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE
United Kingdom
Contributo UE
€ 1 151 649,80
Indirizzo
South Kensington Campus Exhibition Road
SW7 2AZ London

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Tatjana Palalic (Ms.)
KOBENHAVNS UNIVERSITET
Danimarca
Contributo UE
€ 865 050
Indirizzo
Norregade 10
1165 Kobenhavn

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Tipo di attività
Higher or Secondary Education Establishments
Contatto amministrativo
Kristoffersen Ivan (Mr.)
EUROPEAN MOLECULAR BIOLOGY LABORATORY
Germania
Contributo UE
€ 911 396
Indirizzo
Meyerhofstrasse 1
69117 Heidelberg

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Contatto amministrativo
Phil Irving (Dr.)
GOETEBORGS UNIVERSITET
Svezia
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€ 649 999
Indirizzo
Vasaparken
405 30 Goeteborg

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Higher or Secondary Education Establishments
Contatto amministrativo
Ellen Rydberg (Dr.)
VIB VZW
Belgio
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€ 586 590
Indirizzo
Rijvisschestraat 120
9052 Zwijnaarde - Gent

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Contatto amministrativo
Rik Audenaert (Mr.)
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
Francia
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€ 540 000
Indirizzo
3 Avenue Victoria
75000 Paris

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Contatto amministrativo
Alix Pillot (Ms.)
UNIVERSITAET LEIPZIG
Germania
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€ 715 480
Indirizzo
Ritterstrasse 26
04109 Leipzig

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Michael Stumvoll (Prof.)
DANONE RESEARCH SAS
Francia
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€ 159 400
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Route Departementale 128
91767 Palaiseau

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Nicolas Gausseres (Mr.)
CARGILL HAUBOURDIN SAS

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Francia
Contributo UE
€ 19 000
Indirizzo
Rue Du Marechal Joffre 7
59482 Haubourdin
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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Douwina Bosscher (Dr.)
CHALMERS TEKNISKA HOGSKOLA AB
Svezia
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€ 550 000
Indirizzo
-
412 96 Goteborg

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Karin Ryrberg (Ms.)
INSERM TRANSFERT SA
Francia
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€ 496 328
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Rue Watt 7
75013 Paris

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Catherine Clusel (Dr.)
BIOBYTE SOLUTIONS GMBH
Germania
Contributo UE
€ 142 937,20
Indirizzo
Bothestrasse 142
69126 Heidelberg

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Private for-profit entities (excluding Higher or Secondary Education Establishments)
Contatto amministrativo
Ivica Letunic (Dr.)
INST CARDIOMETABOLISME NUTRITION ICAN
Francia
Indirizzo
Boulevard De L'hopital 47-83
75013 Paris

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Marie-Laure Henrotte (Mrs.)
CARGILL R&D CENTRE EUROPE
Belgio
Indirizzo
Havenstraat 84
1800 Vilvoorde

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Doreen Vynck (Mrs.)