Obiettivo RESEARCH AIMS TO UNDERSTAND AT THE MOLECULAR LEVEL THE MECHANISMS OF THE RECOMBINATION OF MT DNA AND ITS ROLE IN REPAIR PROCESSES. It has been shown that the mitochondrial deoxyribonuleic acid (DNA) of Saccharomyces cerevisiae is subject to efficient repair after ultraviolet (UV) light, ethidium bromide or ionising radiation treatments, mainly through a recombinational pathway. An essential member of this repair pathway has been characterised. The PIF1 gene which is required for the efficient recognition of a recombinogenic signal encodes a mitochondrial DNA helicase which is related to a family of multifunctional DNA helicases of Escherichia coli. The gene MIP1 that encodes the mitochondrial DNA polymerase has also been characterised. This enzyme must also play an important role in repair functions and it has been shown that it contributes to the accuracy of the transmissions of the mitochondrial genetic information through the generations. Campo scientifico natural sciencesbiological sciencesgeneticsDNAnatural sciencesphysical sciencesnuclear physicsnatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsenzymes Programma(i) FP1-RADPROT 6C - Multiannual research and training programme (Euratom) in the field of radiation protection, 1985-1989 Argomento(i) Data not available Invito a presentare proposte Data not available Meccanismo di finanziamento CSC - Cost-sharing contracts Coordinatore UNIVERSITE CATHOLIQUE DE LOUVAIN Contributo UE Nessun dato Indirizzo Place De L'Universite 1 LOUVAIN-LA-NEUVE Belgio Mostra sulla mappa Collegamenti Sito web Opens in new window Costo totale Nessun dato
