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World-wide E-infrastructure for structural biology

World-wide E-infrastructure for structural biology

Objective

The focus of structural biology is shifting from single macromolecules produced by simpler prokaryotic organisms, to the macromolecular machinery of higher organisms, including systems of central relevance for human health. Structural biologists are expert in one or more techniques. They now often need to use complementary techniques in which they are less expert. Instruct supports them in using multiple experimental techniques, and visiting multiple experimental facilities, within a single project.
The Protein Data Bank is a public repository for the final structure. Journals require deposition as a precondition of publication. However, metadata is often incomplete.
This project will pilot an infrastructure for storing and processing data that supports the growing use of combined techniques. There are some technique-specific pipelines for data analysis and structure determination. Little is available in terms of automated pipelines to handle integrated datasets. Integrated management of structural biology data from different techniques is lacking altogether.
The proposed activity will integrate the data management facilities that already exist, and enable the provision of new ones. The resulting integration will provide users with an overview of the experiments performed at the different research infrastructures visited, and links to the different data stores. It will extend existing facilities for processing this data. As processing is performed, it will automatically capture metadata reflecting the history of the project. The effort will use existing metadata standards, and integrate with them new domain-specific metadata terms.
This proposal will develop application level service specific to uses cases in structural biology, enabling structural biologists to get the benefit of the generic services developed by EUDAT and the EGI.
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Coordinator

UNITED KINGDOM RESEARCH AND INNOVATION

Address

Polaris House North Star Avenue
Sn2 1fl Swindon

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 780 750

SCIENCE AND TECHNOLOGY FACILITIES COUNCIL

Address

Polaris House North Star Avenue
Sn2 1sz Swindon

United Kingdom

Activity type

Higher or Secondary Education Establishments

Participants (9)

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STICHTING HET NEDERLANDS KANKER INSTITUUT-ANTONI VAN LEEUWENHOEK ZIEKENHUIS

Netherlands

EU Contribution

€ 194 625

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 641 750

Masarykova univerzita

Czechia

EU Contribution

€ 393 250

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 402 500

CONSORZIO INTERUNIVERSITARIO RISONANZE MAGNETICHE DI METALLO PROTEINE

Italy

EU Contribution

€ 421 250

INSTRUCT ACADEMIC SERVICES LIMITED

United Kingdom

EU Contribution

€ 152 750

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 392 250

LUNA SAS

France

EU Contribution

€ 258 000

ISTITUTO NAZIONALE DI FISICA NUCLEARE

Italy

EU Contribution

€ 344 000

Project information

Grant agreement ID: 675858

Status

Closed project

  • Start date

    1 November 2015

  • End date

    31 October 2018

Funded under:

H2020-EU.1.4.1.3.

  • Overall budget:

    € 3 981 125

  • EU contribution

    € 3 981 125

Coordinated by:

UNITED KINGDOM RESEARCH AND INNOVATION

United Kingdom