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European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates

European HIV Vaccine Alliance (EHVA): a EU platform for the discovery and evaluation of novel prophylactic and therapeutic vaccine candidates

Objective

Many HIV vaccine concepts and several efficacy trials have been conducted in the prophylactic and therapeutic fields with limited success. There is an urgent need to develop better vaccines and tools predictive of immunogenicity and of correlates of protection at early stage of vaccine development to mitigate the risks of failure. To address these complex and challenging scientific issues, the European HIV Vaccine Alliance (EHVA) program will develop a Multidisciplinary Vaccine Platform (MVP) in the fields of prophylactic and therapeutic HIV vaccines. The Specific Objectives of the MVP are to build up: 1.Discovery Platform with the goal of generating novel vaccine candidates inducing potent neutralizing and non-neutralizing antibody responses and T-cell responses, 2. Immune Profiling Platform with the goal of ranking novel and existing (benchmark) vaccine candidates on the basis of the immune profile, 3. Data Management/Integration/Down-Selection Platform, with the goal of providing statistical tools for the analysis and interpretation of complex data and algorithms for the efficient selection of vaccines, and 4. Clinical Trials Platform with the goal of accelerating the clinical development of novel vaccines and the early prediction of vaccine failure. EHVA project has developed a global and innovative strategy which includes: a) the multidisciplinary expertise involving immunologists, virologists, structural biology experts, statisticians and computational scientists and clinicians; b) the most innovative technologies to profile immune response and virus reservoir; c) the access to large cohort studies bringing together top European clinical scientists/centres in the fields of prophylactic and therapeutic vaccines, d) the access to a panel of experimental HIV vaccines under clinical development that will be used as benchmark, and e) the liaison to a number of African leading scientists/programs which will foster the testing of future EHVA vaccines through EDCTP
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Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Address

Rue De Tolbiac 101
75654 Paris

France

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 4 418 661,50

Participants (40)

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CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS

Switzerland

SANOFI PASTEUR SA

France

EU Contribution

€ 85 000

CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER

Spain

EU Contribution

€ 915 038,75

HEINRICH-PETTE INSTITUT LEIBNIZ INSTITUT FUER EXPERIMENTELLE VIROLOGIE

Germany

EU Contribution

€ 992 500

IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE

United Kingdom

EU Contribution

€ 1 433 501

ISTITUTO SUPERIORE DI SANITA

Italy

EU Contribution

€ 650 000

UNIVERSITAET REGENSBURG

Germany

EU Contribution

€ 915 000

KAROLINSKA INSTITUTET

Sweden

EU Contribution

€ 465 025

UNIVERSITAT ZURICH

Switzerland

FONDAZIONE PER L'ISTITUTO DI RICERC A IN BIOMEDICINA

Switzerland

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF

Germany

EU Contribution

€ 616 500

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD

United Kingdom

EU Contribution

€ 564 977,50

UNIVERSITE GRENOBLE ALPES

France

EU Contribution

€ 567 637,50

UNIVERSITE JOSEPH FOURIER GRENOBLE 1

France

Academisch Medisch Centrum bij de Universiteit van Amsterdam

Netherlands

EU Contribution

€ 414 937,50

STICHTING BIOMEDICAL PRIMATE RESEARCH CENTER

Netherlands

EU Contribution

€ 1 000 017,50

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN

Germany

EU Contribution

€ 365 000

MEDIZINISCHE UNIVERSITAT INNSBRUCK

Austria

EU Contribution

€ 515 000

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 414 973,75

UNIVERSITE DE LAUSANNE

Switzerland

ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM

Netherlands

EU Contribution

€ 310 000

STICHTING INTERNATIONAL AIDS VACCINE INITIATIVE THE NETHERLANDS

Netherlands

EU Contribution

€ 80 717,75

FIT BIOTECH OY

Finland

EU Contribution

€ 965 190

EUROVACC FOUNDATION

Switzerland

FRED HUTCHINSON CANCER RESEARCH CENTER NON PROFIT CORPORATION

United States

EU Contribution

€ 350 000

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

EU Contribution

€ 707 842

UNIVERSITAET BERN

Switzerland

JANSSEN VACCINES & PREVENTION BV

Netherlands

EU Contribution

€ 84 845

UGANDA NATIONAL HEALTH RESEARCH ORGANISATION

Uganda

EU Contribution

€ 24 985

NATIONAL INSTITUTE FOR MEDICAL RESEARCH

Tanzania

EU Contribution

€ 15 000

Instituto Nacional de Saúde

Mozambique

EU Contribution

€ 15 000

ASSOCIATION PAC-CI

Côte d’Ivoire

EU Contribution

€ 15 000

UNIVERSITY COLLEGE LONDON

United Kingdom

EU Contribution

€ 2 514 226

THE UNIVERSITY OF LIVERPOOL

United Kingdom

EU Contribution

€ 299 999

THE GENERAL HOSPITAL CORPORATION

United States

EU Contribution

€ 100 000

VRIJE UNIVERSITEIT BRUSSEL

Belgium

EU Contribution

€ 149 950

ISTITUTO NAZIONALE PER LE MALATTIE INFETTIVE LAZZARO SPALLANZANI-ISTITUTO DI RICOVERO E CURA A CARATTERE SCIENTIFICO

Italy

EU Contribution

€ 249 963,75

EUROPEAN AIDS TREATMENT GROUP EV

Germany

EU Contribution

€ 50 000

INSERM TRANSFERT SA

France

EU Contribution

€ 445 625

INTERNATIONAL AIDS VACCINE INITIATIVE INC

United States

EU Contribution

€ 1 476 408,25

Project information

Grant agreement ID: 681032

Status

Ongoing project

  • Start date

    1 January 2016

  • End date

    31 December 2020

Funded under:

H2020-EU.3.1.2.

  • Overall budget:

    € 28 135 596,25

  • EU contribution

    € 22 188 521,75

Coordinated by:

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

France