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Role of Tumour Suppressor Gene Products of Common Fragile Sites in Human Diseases

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Publications

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis

Author(s): Saleh Khawaled, Giovanni Nigita, Rosario Distefano, Sara Oster, Sung-Suk Suh, Yoav Smith, Abed Khalaileh, Yong Peng, Carlo M. Croce, Tamar Geiger, Victoria L. Seewaldt, Rami I. Aqeilan
Published in: Signal Transduction and Targeted Therapy, Issue 5/1, 2020, ISSN 2059-3635
DOI: 10.1038/s41392-020-0136-8

Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States

Author(s): Sara Oster, Rami I. Aqeilan
Published in: Cells, Issue 9/8, 2020, Page(s) 1870, ISSN 2073-4409
DOI: 10.3390/cells9081870

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response

Author(s): Idit Hazan, Thomas G. Hofmann, Rami I. Aqeilan
Published in: PLOS Genetics, Issue 12/12, 2016, Page(s) e1006436, ISSN 1553-7404
DOI: 10.1371/journal.pgen.1006436

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Author(s): Mayur Tanna, Rami I. Aqeilan
Published in: Frontiers in Oncology, Issue 8, 2018, ISSN 2234-943X
DOI: 10.3389/fonc.2018.00420

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer

Author(s): Suhaib K. Abdeen, Uri Ben-David, Aya Shweiki, Bella Maly, Rami I. Aqeilan
Published in: Cell Death & Disease, Issue 9/8, 2018, ISSN 2041-4889
DOI: 10.1038/s41419-018-0896-z

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

Author(s): Muhannad Abu-Remaileh, Abed Khalaileh, Eli Pikarsky, Rami I. Aqeilan
Published in: Cell Death & Disease, Issue 9/5, 2018, ISSN 2041-4889
DOI: 10.1038/s41419-018-0510-4

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs

Author(s): Saleh Khawaled, Sung Suk Suh, Suhaib K. Abdeen, Jonathan Monin, Rosario Distefano, Giovanni Nigita, Carlo M. Croce, Rami I. Aqeilan
Published in: Cancer Research, Issue 79/8, 2019, Page(s) 1784-1798, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-18-0614

Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Author(s): Teresa Druck, Douglas G. Cheung, Dongju Park, Francesco Trapasso, Flavia Pichiorri, Marco Gaspari, Tiziana Palumbo, Rami I. Aqeilan, Eugenio Gaudio, Hiroshi Okumura, Rodolfo Iuliano, Cinzia Raso, Kari Green, Kay Huebner, Carlo M. Croce
Published in: Cell Death & Disease, Issue 10/3, 2019, ISSN 2041-4889
DOI: 10.1038/s41419-019-1414-7

WWOX somatic ablation in skeletal muscles alters glucose metabolism

Author(s): Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E. Pacold, Joseph Tam, Rami I. Aqeilan
Published in: Molecular Metabolism, Issue 22, 2019, Page(s) 132-140, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.01.010

Decoding the link between WWOX and p53 in aggressive breast cancer

Author(s): Suhaib K. Abdeen, Rami I. Aqeilan
Published in: Cell Cycle, Issue 18/11, 2019, Page(s) 1177-1186, ISSN 1538-4101
DOI: 10.1080/15384101.2019.1616998

Mapping the breakome reveals tight regulation on oncogenic super-enhancers

Author(s): Sara Oster, Rami I. Aqeilan
Published in: Molecular & Cellular Oncology, Issue 7/3, 2020, Page(s) 1698933, ISSN 2372-3556
DOI: 10.1080/23723556.2019.1698933

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51

Author(s): Idit Hazan, Jonathan Monin, Britta A.M. Bouwman, Nicola Crosetto, Rami I. Aqeilan
Published in: Cell Reports, Issue 29/3, 2019, Page(s) 560-572.e4, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.09.001

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders

Author(s): Nan-Shan Chang, Rongtuan Lin, Chun-I Sze, Rami I. Aqeilan
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
DOI: 10.3389/fonc.2019.00719

Engineering organoids: a promising platform to understand biology and treat diseases

Author(s): Rami I. Aqeilan
Published in: Cell Death & Differentiation, 2021, ISSN 1350-9047
DOI: 10.1038/s41418-020-00680-0