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Targeting common oncogenes with intracellular monobodies

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Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains

Author(s): Grégory La Sala, Camille Michiels, Tim Kükenshöner, Tania Brandstoetter, Barbara Maurer, Akiko Koide, Kelvin Lau, Florence Pojer, Shohei Koide, Veronika Sexl, Laure Dumoutier, Oliver Hantschel
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-17920-z

Selective Targeting of SH2 Domain–Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies

Author(s): Tim Kükenshöner, Nadine Eliane Schmit, Emilie Bouda, Fern Sha, Florence Pojer, Akiko Koide, Markus Seeliger, Shohei Koide, Oliver Hantschel
Published in: Journal of Molecular Biology, Issue 429/9, 2017, Page(s) 1364-1380, ISSN 0022-2836
DOI: 10.1016/j.jmb.2017.03.023

Monobodies as possible next-generation protein therapeutics – a perspective

Author(s): Hantschel, Oliver
Published in: Swiss Medical Weekly, Issue 147/4748, 2017, ISSN 1424-7860
DOI: 10.4414/smw.2017.14545

Structural and functional dissection of the DH and PH domains of oncogenic Bcr-Abl tyrosine kinase

Author(s): Sina Reckel, Charlotte Gehin, Delphine Tardivon, Sandrine Georgeon, Tim Kükenshöner, Frank Löhr, Akiko Koide, Lena Buchner, Alejandro Panjkovich, Aline Reynaud, Sara Pinho, Barbara Gerig, Dmitri Svergun, Florence Pojer, Peter Güntert, Volker Dötsch, Shohei Koide, Anne-Claude Gavin, Oliver Hantschel
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
DOI: 10.1038/s41467-017-02313-6

Monobodies as enabling tools for structural and mechanistic biology

Author(s): Oliver Hantschel, Matthew Biancalana, Shohei Koide
Published in: Current Opinion in Structural Biology, Issue 60, 2020, Page(s) 167-174, ISSN 0959-440X
DOI: 10.1016/

Targeted Protein Degradation through Cytosolic Delivery of Monobody Binders Using Bacterial Toxins

Author(s): Nadine Eliane Schmit, Katyayanee Neopane, Oliver Hantschel
Published in: ACS Chemical Biology, Issue 14/5, 2019, Page(s) 916-924, ISSN 1554-8929
DOI: 10.1021/acschembio.9b00113