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Decisions in metabolic inflammation of the liver: Adhesive interactions involved in leukocyte retention and resolution of inflammation in metabolic-inflammatory liver disease

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Publications

The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution

Author(s): Xiaofei Li, Alessandra Colamatteo, Lydia Kalafati, Tetsuhiro Kajikawa, Hui Wang, Jong-Hyung Lim, Khalil Bdeir, Kyoung-Jin Chung, Xiang Yu, Clorinda Fusco, Antonio Porcellini, Salvatore De Simone, Giuseppe Matarese, Triantafyllos Chavakis, Veronica De Rosa, George Hajishengallis
Published in: Journal of Clinical Investigation, 130/12, 2020, Page(s) 6261-6277, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci137530

Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity

Author(s): Ioannis I. Moustakas, Angeliki Katsarou, Aigli-Ioanna Legaki, Iryna Pyrina, Konstantinos Ntostoglou, Alkistis-Maria Papatheodoridi, Bettina Gercken, Ioannis S. Pateras, Vassilis G. Gorgoulis, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgiou
Published in: International Journal of Molecular Sciences, 22/7, 2021, Page(s) 3446, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073446

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Author(s): Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Published in: The Journal of Immunology, 204/5, 2020, Page(s) 1214-1224, ISSN 0022-1767
Publisher: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Author(s): Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Published in: Cell Reports, 33/7, 2020, Page(s) 108387, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108387

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Author(s): Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink,
Published in: Cell, 183/3, 2020, Page(s) 771-785.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.09.058

Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1

Author(s): Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia Ismini Alexaki, Triantafyllos Chavakis, Yutaka Terao, George Hajishengallis
Published in: JCI Insight, 5/15, 2020, ISSN 2379-3708
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.136706

Regulation of the Bone Marrow Niche by Inflammation

Author(s): Ioannis Mitroulis, Lydia Kalafati, Martin Bornhäuser, George Hajishengallis, Triantafyllos Chavakis
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Roi Gazit
DOI: 10.3389/fimmu.2020.01540

Defining trained immunity and its role in health and disease

Author(s): Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Published in: Nature Reviews Immunology, 20/6, 2020, Page(s) 375-388, ISSN 1474-1733
Publisher: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche

Author(s): Ioannis Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Ioannis Kourtzelis, Matina Economopoulou, Tetsuhiro Kajikawa, Maria Troullinaki, Athanasios Ziogas, Klara Ruppova, Kavita Hosur, Tomoki Maekawa, Baomei Wang, Pallavi Subramanian, Torsten Tonn, Panayotis Verginis, Malte von Bonin, Manja Wobus, Martin Bornhäuser, Tatyana Grinenko, Marianna Di Scala, Andres Hidalgo, Ben Wielockx, George Hajishengall
Published in: Journal of Clinical Investigation, 127/10, 2017, Page(s) 3624-3639, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci92571

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Author(s): Kyoung-Jin Chung, Antonios Chatzigeorgiou, Matina Economopoulou, Ruben Garcia-Martin, Vasileia I Alexaki, Ioannis Mitroulis, Marina Nati, Janine Gebler, Tjalf Ziemssen, Susan E Goelz, Julia Phieler, Jong-Hyung Lim, Katia P Karalis, Thalia Papayannopoulou, Matthias Blüher, George Hajishengallis, Triantafyllos Chavakis
Published in: Nature Immunology, 18/6, 2017, Page(s) 654-664, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/ni.3728

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Author(s): Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx
Published in: Nature Communications, 9/1, 2018, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-018-04188-7

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice

Author(s): Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx
Published in: Stem Cell Reports, 10/6, 2018, Page(s) 1908-1919, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2018.04.012

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Author(s): Ioannis Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, Michal Grzybek, Tatyana Grinenko, Anne Eugster, Maria Troullinaki, Alessandra Palladini, Ioannis Kourtzelis, Antonios Chatzigeorgiou, Andreas Schlitzer, Marc Beyer, Leo A.B. Joosten, Berend Isermann, Mathias Lesche, Andreas Petzold, Kai Simons, Ian Henry, Andreas Dahl, Joachim L. Schultze, Ben Wielockx, Nicola Zamboni, Peter Mirtschink,
Published in: Cell, 172/1-2, 2018, Page(s) 147-161.e12, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2017.11.034

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Author(s): Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann
Published in: Blood, 130/12, 2017, Page(s) 1445-1455, ISSN 0006-4971
Publisher: American Society of Hematology
DOI: 10.1182/blood-2017-02-767921

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies

Author(s): Andreea-Manuela Mirea, Cees J. Tack, Triantafyllos Chavakis, Leo A.B. Joosten, Erik J.M. Toonen
Published in: Trends in Molecular Medicine, 24/5, 2018, Page(s) 458-471, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/j.molmed.2018.03.005

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice

Author(s): Marta Prucnal, Bettina Gercken, Matina Economopoulou, George Hajishengallis, Triantafyllos Chavakis, Pallavi Subramanian
Published in: Thrombosis and Haemostasis, 117/10, 2017, Page(s) 2003-2005, ISSN 0340-6245
Publisher: Schattauer
DOI: 10.1160/th17-03-0160

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Author(s): Michal Grzybek, Alessandra Palladini, Vasileia I. Alexaki, Michal A. Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun
Published in: Molecular Metabolism, 22, 2019, Page(s) 12-20, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.01.009

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Author(s): Baomei Wang, Jong-Hyung Lim, Tetsuhiro Kajikawa, Xiaofei Li, Bruce A. Vallance, Niki M. Moutsopoulos, Triantafyllos Chavakis, George Hajishengallis
Published in: Cell Reports, 26/6, 2019, Page(s) 1614-1626.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.01.054

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

Author(s): Ioannis Kourtzelis, Xiaofei Li, Ioannis Mitroulis, Daniel Grosser, Tetsuhiro Kajikawa, Baomei Wang, Michal Grzybek, Janusz von Renesse, Aleksander Czogalla, Maria Troullinaki, Anaisa Ferreira, Christian Doreth, Klara Ruppova, Lan-Sun Chen, Kavita Hosur, Jong-Hyung Lim, Kyoung-Jin Chung, Sylvia Grossklaus, Anne Kathrin Tausche, Leo A. B. Joosten, Niki M. Moutsopoulos, Ben Wielockx, Antonio Castrill
Published in: Nature Immunology, 20/1, 2019, Page(s) 40-49, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-018-0249-1

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

Author(s): Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
Published in: Cells, 8/2, 2019, Page(s) 155, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells8020155

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Author(s): Triantafyllos Chavakis, Ioannis Mitroulis, George Hajishengallis
Published in: Nature Immunology, 20/7, 2019, Page(s) 802-811, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0402-5

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

Author(s): Aikaterini Hatzioannou, Aggelos Banos, Theodore Sakelaropoulos, Constantinos Fedonidis, Maria-Sophia Vidali, Maren Köhne, Kristian Händler, Louis Boon, Ana Henriques, Vasiliki Koliaraki, Panagiotis Georgiadis, Jerome Zoidakis, Aikaterini Termentzi, Marc Beyer, Triantafyllos Chavakis, Dimitrios Boumpas, Aristotelis Tsirigos, Panayotis Verginis
Published in: Nature Immunology, 21/1, 2020, Page(s) 75-85, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0555-2

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Author(s): Ioannis Kourtzelis, George Hajishengallis, Triantafyllos Chavakis
Published in: Frontiers in Immunology, 11, 2020, ISSN 1664-3224
Publisher: Esther M. Lafuente
DOI: 10.3389/fimmu.2020.00553

Loss of hepatic Mboat7 leads to liver fibrosis

Author(s): Veera Raghavan Thangapandi, Oskar Knittelfelder, Mario Brosch, Eleonora Patsenker, Olga Vvedenskaya, Stephan Buch, Sebastian Hinz, Alexander Hendricks, Marina Nati, Alexander Herrmann, Devavrat Ravindra Rekhade, Thomas Berg, Madlen Matz-Soja, Klaus Huse, Edda Klipp, Josch K Pauling, Judith AH Wodke, Jacobo Miranda Ackerman, Malte von Bonin, Elmar Aigner, Christian Datz, Witigo von Schönfels, Soph
Published in: Gut, 70/5, 2021, Page(s) 940-950, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-320853