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Decisions in metabolic inflammation of the liver: Adhesive interactions involved in leukocyte retention and resolution of inflammation in metabolic-inflammatory liver disease

Publications

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche

Author(s): Ioannis Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Ioannis Kourtzelis, Matina Economopoulou, Tetsuhiro Kajikawa, Maria Troullinaki, Athanasios Ziogas, Klara Ruppova, Kavita Hosur, Tomoki Maekawa, Baomei Wang, Pallavi Subramanian, Torsten Tonn, Panayotis Verginis, Malte von Bonin, Manja Wobus, Martin Bornhäuser, Tatyana Grinenko, Marianna Di Scala, Andres Hidalgo, Ben Wielockx, George Hajishengall
Published in: Journal of Clinical Investigation, Issue 127/10, 2017, Page(s) 3624-3639, ISSN 0021-9738
DOI: 10.1172/jci92571

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Author(s): Kyoung-Jin Chung, Antonios Chatzigeorgiou, Matina Economopoulou, Ruben Garcia-Martin, Vasileia I Alexaki, Ioannis Mitroulis, Marina Nati, Janine Gebler, Tjalf Ziemssen, Susan E Goelz, Julia Phieler, Jong-Hyung Lim, Katia P Karalis, Thalia Papayannopoulou, Matthias Blüher, George Hajishengallis, Triantafyllos Chavakis
Published in: Nature Immunology, Issue 18/6, 2017, Page(s) 654-664, ISSN 1529-2908
DOI: 10.1038/ni.3728

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Author(s): Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx
Published in: Nature Communications, Issue 9/1, 2018, ISSN 2041-1723
DOI: 10.1038/s41467-018-04188-7

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice

Author(s): Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx
Published in: Stem Cell Reports, Issue 10/6, 2018, Page(s) 1908-1919, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2018.04.012

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Author(s): Ioannis Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, Michal Grzybek, Tatyana Grinenko, Anne Eugster, Maria Troullinaki, Alessandra Palladini, Ioannis Kourtzelis, Antonios Chatzigeorgiou, Andreas Schlitzer, Marc Beyer, Leo A.B. Joosten, Berend Isermann, Mathias Lesche, Andreas Petzold, Kai Simons, Ian Henry, Andreas Dahl, Joachim L. Schultze, Ben Wielockx, Nicola Zamboni, Peter Mirtschink,
Published in: Cell, Issue 172/1-2, 2018, Page(s) 147-161.e12, ISSN 0092-8674
DOI: 10.1016/j.cell.2017.11.034

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Author(s): Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann
Published in: Blood, Issue 130/12, 2017, Page(s) 1445-1455, ISSN 0006-4971
DOI: 10.1182/blood-2017-02-767921

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies

Author(s): Andreea-Manuela Mirea, Cees J. Tack, Triantafyllos Chavakis, Leo A.B. Joosten, Erik J.M. Toonen
Published in: Trends in Molecular Medicine, Issue 24/5, 2018, Page(s) 458-471, ISSN 1471-4914
DOI: 10.1016/j.molmed.2018.03.005

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice

Author(s): Marta Prucnal, Bettina Gercken, Matina Economopoulou, George Hajishengallis, Triantafyllos Chavakis, Pallavi Subramanian
Published in: Thrombosis and Haemostasis, Issue 117/10, 2017, Page(s) 2003-2005, ISSN 0340-6245
DOI: 10.1160/th17-03-0160

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Author(s): Michal Grzybek, Alessandra Palladini, Vasileia I. Alexaki, Michal A. Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun
Published in: Molecular Metabolism, Issue 22, 2019, Page(s) 12-20, ISSN 2212-8778
DOI: 10.1016/j.molmet.2019.01.009

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Author(s): Baomei Wang, Jong-Hyung Lim, Tetsuhiro Kajikawa, Xiaofei Li, Bruce A. Vallance, Niki M. Moutsopoulos, Triantafyllos Chavakis, George Hajishengallis
Published in: Cell Reports, Issue 26/6, 2019, Page(s) 1614-1626.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.01.054

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

Author(s): Ioannis Kourtzelis, Xiaofei Li, Ioannis Mitroulis, Daniel Grosser, Tetsuhiro Kajikawa, Baomei Wang, Michal Grzybek, Janusz von Renesse, Aleksander Czogalla, Maria Troullinaki, Anaisa Ferreira, Christian Doreth, Klara Ruppova, Lan-Sun Chen, Kavita Hosur, Jong-Hyung Lim, Kyoung-Jin Chung, Sylvia Grossklaus, Anne Kathrin Tausche, Leo A. B. Joosten, Niki M. Moutsopoulos, Ben Wielockx, Antonio Castrill
Published in: Nature Immunology, Issue 20/1, 2019, Page(s) 40-49, ISSN 1529-2908
DOI: 10.1038/s41590-018-0249-1

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

Author(s): Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
Published in: Cells, Issue 8/2, 2019, Page(s) 155, ISSN 2073-4409
DOI: 10.3390/cells8020155

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Author(s): Triantafyllos Chavakis, Ioannis Mitroulis, George Hajishengallis
Published in: Nature Immunology, Issue 20/7, 2019, Page(s) 802-811, ISSN 1529-2908
DOI: 10.1038/s41590-019-0402-5