Decisions in metabolic inflammation of the liver: Adhesive interactions involved in leukocyte retention and resolution of inflammation in metabolic-inflammatory liver disease

Informazioni relative al progetto

DEMETINL

ID dell’accordo di sovvenzione: 683145

DOI 10.3030/683145

Progetto chiuso

Data della firma CE 9 Giugno 2016

Data di avvio 1 Gennaio 2017

Data di completamento 31 Ottobre 2022

Finanziato da

• EXCELLENT SCIENCE - European Research Council (ERC)

Costo totale € 1 953 250,00

Contributo UE € 1 953 250,00

Coordinato da

TECHNISCHE UNIVERSITAET DRESDEN
Germany

Pubblicazioni

Peer reviewed articles (28)

The role of neutrophils in trained immunity

Autori: Lydia Kalafati, Aikaterini Hatzioannou, George Hajishengallis, Triantafyllos Chavakis
Pubblicato in: Immunological Reviews, 2022, ISSN 0105-2896
Editore: Blackwell Publishing Inc.
DOI: 10.1111/imr.13142

The RNA binding protein human antigen R is a gatekeeper of liver homeostasis

Autori: Pallavi Subramanian, Sofia Gargani, Alessandra Palladini, Margarita Chatzimike, Michal Grzybek, Mirko Peitzsch, Anastasios D. Papanastasiou, Iryna Pyrina, Vasileios Ntafis, Bettina Gercken, Mathias Lesche, Andreas Petzold, Anupam Sinha, Marina Nati, Veera Raghavan Thangapandi, Ioannis Kourtzelis, Margarita Andreadou, Anke Witt, Andreas Dahl, Ralph Burkhardt, Robert Haase, António Miguel de Jesus
Pubblicato in: Hepatology, Numero Volume75, Numero4, 2022, Pagina/e Pages 881-897, ISSN 0270-9139
Editore: John Wiley & Sons Inc.
DOI: 10.1002/hep.32153

The DEL-1/β3 integrin axis promotes regulatory T cell responses during inflammation resolution

Autori: Xiaofei Li, Alessandra Colamatteo, Lydia Kalafati, Tetsuhiro Kajikawa, Hui Wang, Jong-Hyung Lim, Khalil Bdeir, Kyoung-Jin Chung, Xiang Yu, Clorinda Fusco, Antonio Porcellini, Salvatore De Simone, Giuseppe Matarese, Triantafyllos Chavakis, Veronica De Rosa, George Hajishengallis
Pubblicato in: Journal of Clinical Investigation, Numero 130/12, 2020, Pagina/e 6261-6277, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci137530

Hepatic Senescence Accompanies the Development of NAFLD in Non-Aged Mice Independently of Obesity

Autori: Ioannis I. Moustakas, Angeliki Katsarou, Aigli-Ioanna Legaki, Iryna Pyrina, Konstantinos Ntostoglou, Alkistis-Maria Papatheodoridi, Bettina Gercken, Ioannis S. Pateras, Vassilis G. Gorgoulis, Michael Koutsilieris, Triantafyllos Chavakis, Antonios Chatzigeorgiou
Pubblicato in: International Journal of Molecular Sciences, Numero 22/7, 2021, Pagina/e 3446, ISSN 1422-0067
Editore: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22073446

DHEA Inhibits Leukocyte Recruitment through Regulation of the Integrin Antagonist DEL-1

Autori: Athanasios Ziogas, Tomoki Maekawa, Johannes R. Wiessner, Thi Trang Le, David Sprott, Maria Troullinaki, Ales Neuwirth, Vasiliki Anastasopoulou, Sylvia Grossklaus, Kyoung-Jin Chung, Markus Sperandio, Triantafyllos Chavakis, George Hajishengallis, Vasileia Ismini Alexaki
Pubblicato in: The Journal of Immunology, Numero 204/5, 2020, Pagina/e 1214-1224, ISSN 0022-1767
Editore: American Association of Immunologists
DOI: 10.4049/jimmunol.1900746

BCG Vaccination Induces Long-Term Functional Reprogramming of Human Neutrophils

Autori: Simone J.C.F.M. Moorlag, Yessica Alina Rodriguez-Rosales, Joshua Gillard, Stephanie Fanucchi, Kate Theunissen, Boris Novakovic, Cynthia M. de Bont, Yutaka Negishi, Ezio T. Fok, Lydia Kalafati, Panayotis Verginis, Vera P. Mourits, Valerie A.C.M. Koeken, L. Charlotte J. de Bree, Ger J.M. Pruijn, Craig Fenwick, Reinout van Crevel, Leo A.B. Joosten, Irma Joosten, Hans Koenen, Musa M. Mhlanga, Dimitri
Pubblicato in: Cell Reports, Numero 33/7, 2020, Pagina/e 108387, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2020.108387

Innate Immune Training of Granulopoiesis Promotes Anti-tumor Activity

Autori: Lydia Kalafati, Ioannis Kourtzelis, Jonas Schulte-Schrepping, Xiaofei Li, Aikaterini Hatzioannou, Tatyana Grinenko, Eman Hagag, Anupam Sinha, Canan Has, Sevina Dietz, Antonio Miguel de Jesus Domingues, Marina Nati, Sundary Sormendi, Ales Neuwirth, Antonios Chatzigeorgiou, Athanasios Ziogas, Mathias Lesche, Andreas Dahl, Ian Henry, Pallavi Subramanian, Ben Wielockx, Peter Murray, Peter Mirtschink,
Pubblicato in: Cell, Numero 183/3, 2020, Pagina/e 771-785.e12, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2020.09.058

Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1

Autori: Tomoki Maekawa, Hikaru Tamura, Hisanori Domon, Takumi Hiyoshi, Toshihito Isono, Daisuke Yonezawa, Naoki Hayashi, Naoki Takahashi, Koichi Tabeta, Takeyasu Maeda, Masataka Oda, Athanasios Ziogas, Vasileia Ismini Alexaki, Triantafyllos Chavakis, Yutaka Terao, George Hajishengallis
Pubblicato in: JCI Insight, Numero 5/15, 2020, ISSN 2379-3708
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci.insight.136706

Immunometabolism: Where Immunology and Metabolism Meet

Autori: Triantafyllos Chavakis
Pubblicato in: Journal of Innate Immunity, Numero 2022, Vol.14, 2022, Pagina/e 1–3, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000521305

Regulation of the Bone Marrow Niche by Inflammation

Autori: Ioannis Mitroulis, Lydia Kalafati, Martin Bornhäuser, George Hajishengallis, Triantafyllos Chavakis
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Roi Gazit
DOI: 10.3389/fimmu.2020.01540

Defining trained immunity and its role in health and disease

Autori: Mihai G. Netea, Jorge Domínguez-Andrés, Luis B. Barreiro, Triantafyllos Chavakis, Maziar Divangahi, Elaine Fuchs, Leo A. B. Joosten, Jos W. M. van der Meer, Musa M. Mhlanga, Willem J. M. Mulder, Niels P. Riksen, Andreas Schlitzer, Joachim L. Schultze, Christine Stabell Benn, Joseph C. Sun, Ramnik J. Xavier, Eicke Latz
Pubblicato in: Nature Reviews Immunology, Numero 20/6, 2020, Pagina/e 375-388, ISSN 1474-1733
Editore: Nature Publishing Group
DOI: 10.1038/s41577-020-0285-6

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche

Autori: Ioannis Mitroulis, Lan-Sun Chen, Rashim Pal Singh, Ioannis Kourtzelis, Matina Economopoulou, Tetsuhiro Kajikawa, Maria Troullinaki, Athanasios Ziogas, Klara Ruppova, Kavita Hosur, Tomoki Maekawa, Baomei Wang, Pallavi Subramanian, Torsten Tonn, Panayotis Verginis, Malte von Bonin, Manja Wobus, Martin Bornhäuser, Tatyana Grinenko, Marianna Di Scala, Andres Hidalgo, Ben Wielockx, George Hajishengall
Pubblicato in: Journal of Clinical Investigation, Numero 127/10, 2017, Pagina/e 3624-3639, ISSN 0021-9738
Editore: American Society for Clinical Investigation
DOI: 10.1172/jci92571

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Autori: Kyoung-Jin Chung, Antonios Chatzigeorgiou, Matina Economopoulou, Ruben Garcia-Martin, Vasileia I Alexaki, Ioannis Mitroulis, Marina Nati, Janine Gebler, Tjalf Ziemssen, Susan E Goelz, Julia Phieler, Jong-Hyung Lim, Katia P Karalis, Thalia Papayannopoulou, Matthias Blüher, George Hajishengallis, Triantafyllos Chavakis
Pubblicato in: Nature Immunology, Numero 18/6, 2017, Pagina/e 654-664, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/ni.3728

Hematopoietic stem cells can differentiate into restricted myeloid progenitors before cell division in mice

Autori: Tatyana Grinenko, Anne Eugster, Lars Thielecke, Beáta Ramasz, Anja Krüger, Sevina Dietz, Ingmar Glauche, Alexander Gerbaulet, Malte von Bonin, Onur Basak, Hans Clevers, Triantafyllos Chavakis, Ben Wielockx
Pubblicato in: Nature Communications, Numero 9/1, 2018, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/s41467-018-04188-7

Hematopoietic Stem Cells but Not Multipotent Progenitors Drive Erythropoiesis during Chronic Erythroid Stress in EPO Transgenic Mice

Autori: Rashim Pal Singh, Tatyana Grinenko, Beáta Ramasz, Kristin Franke, Mathias Lesche, Andreas Dahl, Max Gassmann, Triantafyllos Chavakis, Ian Henry, Ben Wielockx
Pubblicato in: Stem Cell Reports, Numero 10/6, 2018, Pagina/e 1908-1919, ISSN 2213-6711
Editore: Cell Press
DOI: 10.1016/j.stemcr.2018.04.012

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Autori: Ioannis Mitroulis, Klara Ruppova, Baomei Wang, Lan-Sun Chen, Michal Grzybek, Tatyana Grinenko, Anne Eugster, Maria Troullinaki, Alessandra Palladini, Ioannis Kourtzelis, Antonios Chatzigeorgiou, Andreas Schlitzer, Marc Beyer, Leo A.B. Joosten, Berend Isermann, Mathias Lesche, Andreas Petzold, Kai Simons, Ian Henry, Andreas Dahl, Joachim L. Schultze, Ben Wielockx, Nicola Zamboni, Peter Mirtschink,
Pubblicato in: Cell, Numero 172/1-2, 2018, Pagina/e 147-161.e12, ISSN 0092-8674
Editore: Cell Press
DOI: 10.1016/j.cell.2017.11.034

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function

Autori: Thati Madhusudhan, Hongjie Wang, Sanchita Ghosh, Wei Dong, Varun Kumar, Moh'd Mohanad Al-Dabet, Jayakumar Manoharan, Sumra Nazir, Ahmed Elwakiel, Fabian Bock, Shrey Kohli, Andi Marquardt, Ibrahim Sögüt, Khurrum Shahzad, Andreas J. Müller, Charles T. Esmon, Peter P. Nawroth, Jochen Reiser, Triantafyllos Chavakis, Wolfram Ruf, Berend Isermann
Pubblicato in: Blood, Numero 130/12, 2017, Pagina/e 1445-1455, ISSN 0006-4971
Editore: American Society of Hematology
DOI: 10.1182/blood-2017-02-767921

IL-1 Family Cytokine Pathways Underlying NAFLD: Towards New Treatment Strategies

Autori: Andreea-Manuela Mirea, Cees J. Tack, Triantafyllos Chavakis, Leo A.B. Joosten, Erik J.M. Toonen
Pubblicato in: Trends in Molecular Medicine, Numero 24/5, 2018, Pagina/e 458-471, ISSN 1471-4914
Editore: Elsevier BV
DOI: 10.1016/j.molmed.2018.03.005

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice

Autori: Marta Prucnal, Bettina Gercken, Matina Economopoulou, George Hajishengallis, Triantafyllos Chavakis, Pallavi Subramanian
Pubblicato in: Thrombosis and Haemostasis, Numero 117/10, 2017, Pagina/e 2003-2005, ISSN 0340-6245
Editore: Schattauer
DOI: 10.1160/th17-03-0160

Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Autori: Michal Grzybek, Alessandra Palladini, Vasileia I. Alexaki, Michal A. Surma, Kai Simons, Triantafyllos Chavakis, Christian Klose, Ünal Coskun
Pubblicato in: Molecular Metabolism, Numero 22, 2019, Pagina/e 12-20, ISSN 2212-8778
Editore: Elsevier GmbH
DOI: 10.1016/j.molmet.2019.01.009

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

Autori: Baomei Wang, Jong-Hyung Lim, Tetsuhiro Kajikawa, Xiaofei Li, Bruce A. Vallance, Niki M. Moutsopoulos, Triantafyllos Chavakis, George Hajishengallis
Pubblicato in: Cell Reports, Numero 26/6, 2019, Pagina/e 1614-1626.e5, ISSN 2211-1247
Editore: Cell Press
DOI: 10.1016/j.celrep.2019.01.054

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

Autori: Ioannis Kourtzelis, Xiaofei Li, Ioannis Mitroulis, Daniel Grosser, Tetsuhiro Kajikawa, Baomei Wang, Michal Grzybek, Janusz von Renesse, Aleksander Czogalla, Maria Troullinaki, Anaisa Ferreira, Christian Doreth, Klara Ruppova, Lan-Sun Chen, Kavita Hosur, Jong-Hyung Lim, Kyoung-Jin Chung, Sylvia Grossklaus, Anne Kathrin Tausche, Leo A. B. Joosten, Niki M. Moutsopoulos, Ben Wielockx, Antonio Castrill
Pubblicato in: Nature Immunology, Numero 20/1, 2019, Pagina/e 40-49, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-018-0249-1

Hypoxia Pathway Proteins in Normal and Malignant Hematopoiesis

Autori: Ben Wielockx, Tatyana Grinenko, Peter Mirtschink, Triantafyllos Chavakis
Pubblicato in: Cells, Numero 8/2, 2019, Pagina/e 155, ISSN 2073-4409
Editore: MDPI AG
DOI: 10.3390/cells8020155

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

Autori: Triantafyllos Chavakis, Ioannis Mitroulis, George Hajishengallis
Pubblicato in: Nature Immunology, Numero 20/7, 2019, Pagina/e 802-811, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0402-5

The Role of Innate Immune Cells in Nonalcoholic Fatty Liver Disease

Autori: Nati M.; Chung K.-J.; Chavakis T.
Pubblicato in: Journal of Innate Immunity, Numero Vol.14; 1, 2022, Pagina/e 31–41, ISSN 1662-811X
Editore: Karger AG
DOI: 10.1159/000518407

An intrinsic role of IL-33 in Treg cell–mediated tumor immunoevasion

Autori: Aikaterini Hatzioannou, Aggelos Banos, Theodore Sakelaropoulos, Constantinos Fedonidis, Maria-Sophia Vidali, Maren Köhne, Kristian Händler, Louis Boon, Ana Henriques, Vasiliki Koliaraki, Panagiotis Georgiadis, Jerome Zoidakis, Aikaterini Termentzi, Marc Beyer, Triantafyllos Chavakis, Dimitrios Boumpas, Aristotelis Tsirigos, Panayotis Verginis
Pubblicato in: Nature Immunology, Numero 21/1, 2020, Pagina/e 75-85, ISSN 1529-2908
Editore: Nature Publishing Group
DOI: 10.1038/s41590-019-0555-2

Phagocytosis of Apoptotic Cells in Resolution of Inflammation

Autori: Ioannis Kourtzelis, George Hajishengallis, Triantafyllos Chavakis
Pubblicato in: Frontiers in Immunology, Numero 11, 2020, ISSN 1664-3224
Editore: Esther M. Lafuente
DOI: 10.3389/fimmu.2020.00553

Loss of hepatic Mboat7 leads to liver fibrosis

Autori: Veera Raghavan Thangapandi, Oskar Knittelfelder, Mario Brosch, Eleonora Patsenker, Olga Vvedenskaya, Stephan Buch, Sebastian Hinz, Alexander Hendricks, Marina Nati, Alexander Herrmann, Devavrat Ravindra Rekhade, Thomas Berg, Madlen Matz-Soja, Klaus Huse, Edda Klipp, Josch K Pauling, Judith AH Wodke, Jacobo Miranda Ackerman, Malte von Bonin, Elmar Aigner, Christian Datz, Witigo von Schönfels, Soph
Pubblicato in: Gut, Numero 70/5, 2021, Pagina/e 940-950, ISSN 0017-5749
Editore: BMJ Publishing Group
DOI: 10.1136/gutjnl-2020-320853