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Towards Novel Inert (Photo-)toxic Ru(II) Polypyridyl Complexes

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Publications

Monomeric and dimeric coordinatively saturated and substitutionally inert Ru( ii ) polypyridyl complexes as anticancer drug candidates

Author(s): Anna Notaro, Gilles Gasser
Published in: Chemical Society Reviews, Issue 46/23, 2017, Page(s) 7317-7337, ISSN 0306-0012
DOI: 10.1039/C7CS00356K

Critical Overview of the Use of Ru(II) Polypyridyl Complexes as Photosensitizers in One-Photon and Two-Photon Photodynamic Therapy

Author(s): Franz Heinemann, Johannes Karges, Gilles Gasser
Published in: Accounts of Chemical Research, Issue 50/11, 2017, Page(s) 2727-2736, ISSN 0001-4842
DOI: 10.1021/acs.accounts.7b00180

ATR-Mediated Global Fork Slowing and Reversal Assist Fork Traverse and Prevent Chromosomal Breakage at DNA Interstrand Cross-Links

Author(s): Karun Mutreja, Jana Krietsch, Jeannine Hess, Sebastian Ursich, Matteo Berti, Fabienne K. Roessler, Ralph Zellweger, Malay Patra, Gilles Gasser, Massimo Lopes
Published in: Cell Reports, Issue 24/10, 2018, Page(s) 2629-2642.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2018.08.019

Synthesis, Characterization, and Biological Evaluation of Red-Absorbing Fe(II) Polypyridine Complexes

Author(s): Johannes Karges, Philippe Goldner, Gilles Gasser
Published in: Inorganics, Issue 7/1, 2019, Page(s) 4, ISSN 2304-6740
DOI: 10.3390/inorganics7010004

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

Author(s): Marie Flamme, Emma Clarke, Gilles Gasser, Marcel Hollenstein
Published in: Molecules, Issue 23/7, 2018, Page(s) 1515, ISSN 1420-3049
DOI: 10.3390/molecules23071515

Mesoporous silica nanoparticles functionalised with a photoactive ruthenium( ii ) complex: exploring the formulation of a metal-based photodynamic therapy photosensitiser

Author(s): Younes Ellahioui, Malay Patra, Cristina Mari, Rim Kaabi, Johannes Karges, Gilles Gasser, Santiago Gómez-Ruiz
Published in: Dalton Transactions, Issue 48/18, 2019, Page(s) 5940-5951, ISSN 1477-9226
DOI: 10.1039/c8dt02392a

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium( i ) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Author(s): Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis
Published in: Journal of Materials Chemistry B, Issue 6/47, 2018, Page(s) 7805-7810, ISSN 2050-7518
DOI: 10.1039/C8TB02464B

Biological Evaluation of the NIR-Emissive Ruby Analogue [Cr(ddpd) 2 ][BF 4 ] 3 as a Photodynamic Therapy Photosensitizer

Author(s): Uttara Basu, Sven Otto, Katja Heinze, Gilles Gasser
Published in: European Journal of Inorganic Chemistry, Issue 2019/1, 2019, Page(s) 37-41, ISSN 1434-1948
DOI: 10.1002/ejic.201801023

Mechanisms of action of Ru( ii ) polypyridyl complexes in living cells upon light irradiation

Author(s): Marta Jakubaszek, Bruno Goud, Stefano Ferrari, Gilles Gasser
Published in: Chemical Communications, Issue 54/93, 2018, Page(s) 13040-13059, ISSN 1359-7345
DOI: 10.1039/C8CC05928D

Synthesis, characterization and biological activity of organometallic derivatives of the antimalarial drug mefloquine as new antischistosomal drug candidates

Author(s): Faustine d'Orchymont, Jeannine Hess, Gordana Panic, Marta Jakubaszek, Lea Gemperle, Jennifer Keiser, Gilles Gasser
Published in: MedChemComm, Issue 9/11, 2018, Page(s) 1905-1909, ISSN 2040-2503
DOI: 10.1039/c8md00396c

Targeting of the mitochondrion by dinuclear thiolato-bridged arene ruthenium complexes in cancer cells and in the apicomplexan parasite Neospora caninum

Author(s): Afonso P. Basto, Nicoleta Anghel, Riccardo Rubbiani, Joachim Müller, David Stibal, Federico Giannini, Georg Süss-Fink, Vreni Balmer, Gilles Gasser, Julien Furrer, Andrew Hemphill
Published in: Metallomics, Issue 11/2, 2019, Page(s) 462-474, ISSN 1756-5901
DOI: 10.1039/c8mt00307f

Polymer encapsulation of ruthenium complexes for biological and medicinal applications

Author(s): Elise Villemin, Yih Ching Ong, Christophe M. Thomas, Gilles Gasser
Published in: Nature Reviews Chemistry, Issue 3/4, 2019, Page(s) 261-282, ISSN 2397-3358
DOI: 10.1038/s41570-019-0088-0

Targeted photoredox catalysis in cancer cells

Author(s): Huaiyi Huang, Samya Banerjee, Kangqiang Qiu, Pingyu Zhang, Olivier Blacque, Thomas Malcomson, Martin J. Paterson, Guy J. Clarkson, Michael Staniforth, Vasilios G. Stavros, Gilles Gasser, Hui Chao, Peter J. Sadler
Published in: Nature Chemistry, Issue 11/11, 2019, Page(s) 1041-1048, ISSN 1755-4330
DOI: 10.1038/s41557-019-0328-4

Towards Long Wavelength Absorbing Photodynamic Therapy Photosensitizers via the Extension of a [Ru(bipy) 3 ] 2+ Core

Author(s): Johannes Karges, Olivier Blacque, Philippe Goldner, Hui Chao, Gilles Gasser
Published in: European Journal of Inorganic Chemistry, Issue 2019/32, 2019, Page(s) 3704-3712, ISSN 1434-1948
DOI: 10.1002/ejic.201900569

Polymeric Bis(dipyrrinato) Zinc(II) Nanoparticles as Selective Imaging Probes for Lysosomes of Cancer Cells

Author(s): Johannes Karges, Olivier Blacque, Hui Chao, Gilles Gasser
Published in: Inorganic Chemistry, Issue 58/18, 2019, Page(s) 12422-12432, ISSN 0020-1669
DOI: 10.1021/acs.inorgchem.9b02019

Synthesis and Characterization of an Epidermal Growth Factor Receptor‐Selective Ru II Polypyridyl–Nanobody Conjugate as a Photosensitizer for Photodynamic Therapy

Author(s): Johannes Karges, Marta Jakubaszek, Cristina Mari, Kristof Zarschler, Bruno Goud, Holger Stephan, Gilles Gasser
Published in: ChemBioChem, 2019, ISSN 1439-4227
DOI: 10.1002/cbic.201900419

Polymeric Encapsulation of Novel Homoleptic Bis(dipyrrinato) Zinc(II) Complexes with Long Lifetimes for Applications as Photodynamic Therapy Photosensitisers

Author(s): Johannes Karges, Uttara Basu, Olivier Blacque, Hui Chao, Gilles Gasser
Published in: Angewandte Chemie International Edition, Issue 58/40, 2019, Page(s) 14334-14340, ISSN 1433-7851
DOI: 10.1002/anie.201907856

Synthesis, Characterisation and Biological Evaluation of π-Extended Fe(II) Bipyridine Complexes as Potential Photosensitizers for Photodynamic Therapy

Author(s): Johannes Karges, Gilles Gasser
Published in: Inorganica Chimica Acta, Issue 499, 2020, Page(s) 119196, ISSN 0020-1693
DOI: 10.1016/j.ica.2019.119196

Towards Light‐Activated Ruthenium–Arene (RAPTA‐Type) Prodrug Candidates

Author(s): Anna K. Renfrew, Johannes Karges, Rosario Scopelliti, Felix D. Bobbink, Patrycja Nowak‐Sliwinska, Gilles Gasser, Paul J. Dyson
Published in: ChemBioChem, Issue 20/22, 2019, Page(s) 2876-2882, ISSN 1439-4227
DOI: 10.1002/cbic.201900236

Systematic investigation of the antiproliferative activity of a series of ruthenium terpyridine complexes

Author(s): Johannes Karges, Olivier Blacque, Marta Jakubaszek, Bruno Goud, Philippe Goldner, Gilles Gasser
Published in: Journal of Inorganic Biochemistry, Issue 198, 2019, Page(s) 110752, ISSN 0162-0134
DOI: 10.1016/j.jinorgbio.2019.110752

A Ru(II) polypyridyl complex bearing aldehyde functions as a versatile synthetic precursor for long-wavelength absorbing photodynamic therapy photosensitizers

Author(s): Johannes Karges, Franz Heinemann, Federica Maschietto, Malay Patra, Olivier Blacque, Ilaria Ciofini, Bernhard Spingler, Gilles Gasser
Published in: Bioorganic & Medicinal Chemistry, Issue 27/12, 2019, Page(s) 2666-2675, ISSN 0968-0896
DOI: 10.1016/j.bmc.2019.05.011

Evaluation of the Potential of Cobalamin Derivatives Bearing Ru(II) Polypyridyl Complexes as Photosensitizers for Photodynamic Therapy

Author(s): Marta Jakubaszek, Jeremie Rossier, Johannes Karges, Joachim Delasoie, Bruno Goud, Gilles Gasser, Fabio Zobi
Published in: Helvetica Chimica Acta, Issue 102/7, 2019, ISSN 0018-019X
DOI: 10.1002/hlca.201900104