Objective Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide. Fields of science natural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineimmunologymedical and health sciencesclinical medicinepsychiatryschizophreniamedical and health sciencesbasic medicineneurologynatural sciencesbiological sciencesgeneticsepigenetics Keywords Schizophrenia biomarkers early detection Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.3. - Stimulating innovation by means of cross-fertilisation of knowledge Topic(s) MSCA-RISE-2016 - Research and Innovation Staff Exchange Call for proposal H2020-MSCA-RISE-2016 See other projects for this call Funding Scheme MSCA-RISE - Marie Skłodowska-Curie Research and Innovation Staff Exchange (RISE) Coordinator PROTOBIOS OU Net EU contribution € 342 000,00 Address MAEALUSE 4 12618 Tallinn Estonia See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Eesti Eesti Põhja-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 342 000,00 Participants (11) Sort alphabetically Sort by Net EU contribution Expand all Collapse all TARTU ULIKOOL Estonia Net EU contribution € 40 500,00 Address ULIKOOLI 18 51005 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 40 500,00 SIHTASUTUS TARTU ULIKOOLI KLIINIKUM Estonia Net EU contribution € 9 000,00 Address PUUSEPA 1A 50406 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 9 000,00 TALLINNA TEHNIKAÜLIKOOL Estonia Net EU contribution € 67 500,00 Address EHITAJATE TEE 5 12616 Tallinn See on map Region Eesti Eesti Põhja-Eesti Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 67 500,00 KING'S COLLEGE LONDON United Kingdom Net EU contribution € 76 500,00 Address STRAND WC2R 2LS London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 76 500,00 HELSINGIN YLIOPISTO Finland Net EU contribution € 121 500,00 Address YLIOPISTONKATU 3 00014 Helsingin Yliopisto See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 121 500,00 HUS-YHTYMA Participation ended Finland Net EU contribution € 0,00 Address STENBACKINKATU 9 00029 Helsinki See on map Region Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data ELVESYS France Net EU contribution € 4 500,00 Address 172 RUE DE CHARONNE B2 2 EME ETAGE 75011 Paris See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 4 500,00 OU QURETEC Estonia Net EU contribution € 85 500,00 Address ULIKOOLI 6A 51003 Tartu See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Eesti Eesti Lõuna-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 85 500,00 LINKOPINGS UNIVERSITET Sweden Net EU contribution € 22 500,00 Address CAMPUS VALLA 581 83 Linkoping See on map Region Östra Sverige Östra Mellansverige Östergötlands län Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 22 500,00 SYSTASY BIOSCIENCE GMBH Germany Net EU contribution € 180 000,00 Address BALANSTR. 6 81669 Munchen See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 180 000,00 LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Germany Net EU contribution € 40 500,00 Address GESCHWISTER SCHOLL PLATZ 1 80539 Muenchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 40 500,00