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Towards Early Molecular Diagnostics of Schizophrenia

Objective

Schizophrenia (SZ) is a severe mental disorder affecting more than 0.7% of the adult population. One of the most disabling and emotionally devastating illnesses known to man, SZ is also associated with considerable socioeconomic burden. In general, the chronic nature and the high degree of patient disability make SZ the fourth leading cause of disease burden across the globe with the management costs making up ~3% of the total healthcare budget in the Western countries. The situation is even direr in some regions, including northern Sweden and Finland, where relative prevalence of SZ exceeds two to three times corresponding national or regional averages. Poorly understood aetiology and limited diagnostic arsenal make it difficult to detect and treat SZ in a timely and efficient manner. This underscores a critical need for better understanding of the mechanisms underlying SZ and development of new diagnostic possibilities allowing its early detection, ideally prior to the onset of psychosis. The SZ_TEST will address these challenges by coordinating efforts with complementary areas of expertise in genetics, epigenetics, neurodevelopment, molecular psychiatry, clinical immunology and biotech R&D. The overarching hypothesis underlying our work is that genetic vulnerabilities, neurodevelopmental defects, exposure to pathogens, immune system status and specific lifestyle choices may compound the risk of SZ and that a systematic multivariate analysis of these factors should result in substantially improved diagnostic tools. SZ_TEST will work towards the development of molecular diagnostics tools for early detection of SZ, by using relevant cohorts of human subjects, unique animal and cell models, and combining unbiased high-throughput omic screens with knowledge-based candidate marker analyses. SZ_TEST training network is expected to have a major impact on improving the quality of life and reducing the health care costs in Europe and worldwide.

Coordinator

PROTOBIOS OU
Net EU contribution
€ 342 000,00
Address
Maealuse 4
12618 Tallinn
Estonia

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Region
Eesti Eesti Põhja-Eesti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Participants (11)

TARTU ULIKOOL
Estonia
Net EU contribution
€ 40 500,00
Address
Ulikooli 18
51005 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SIHTASUTUS TARTU ULIKOOLI KLIINIKUM
Estonia
Net EU contribution
€ 9 000,00
Address
Puusepa 1a
50406 Tartu

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Research Organisations
Non-EU contribution
€ 0,00
TALLINNA TEHNIKAÜLIKOOL
Estonia
Net EU contribution
€ 67 500,00
Address
Ehitajate Tee 5
12616 Tallinn

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Region
Eesti Eesti Lõuna-Eesti
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 76 500,00
Address
Strand
WC2R 2LS London

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Region
London Inner London — West Westminster
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HELSINGIN YLIOPISTO
Finland
Net EU contribution
€ 121 500,00
Address
Yliopistonkatu 3
00014 Helsingin Yliopisto

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ

Participation ended

Finland
Net EU contribution
€ 0,00
Address
Stenbackinkatu 9
00029 Helsinki

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Region
Manner-Suomi Helsinki-Uusimaa Helsinki-Uusimaa
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ELVESYS
France
Net EU contribution
€ 4 500,00
Address
172 Rue De Charonne B2 2 Eme Etage
75011 Paris

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Ile-de-France Ile-de-France Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
OU QURETEC
Estonia
Net EU contribution
€ 85 500,00
Address
Ulikooli 6a
51003 Tartu

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Eesti Eesti Lõuna-Eesti
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LINKOPINGS UNIVERSITET
Sweden
Net EU contribution
€ 22 500,00
Address
Campus Valla
581 83 Linkoping

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Region
Östra Sverige Östra Mellansverige Östergötlands län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SYSTASY BIOSCIENCE GMBH
Germany
Net EU contribution
€ 180 000,00
Address
Balanstr. 6
81669 Munchen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Germany
Net EU contribution
€ 40 500,00
Address
Geschwister Scholl Platz 1
80539 Muenchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00