Towards Early Molecular Diagnostics of Schizophrenia

Project Information

SZ_TEST

Grant agreement ID: 734791

DOI 10.3030/734791

Project closed

EC signature date 5 December 2016

Start date 1 January 2017

End date 30 June 2022

Funded under

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Total cost € 990 000,00

EU contribution € 990 000,00

Coordinated by

PROTOBIOS OU
Estonia

Deliverables

Other (2)

Dissemination and communication plan

Dissemination and communication plan, responsible partner: PB, M5

SZ_TEST events

Project events taking place in months 12 24 36 66

Websites, patent fillings, videos etc. (1)

Promotional materials including a dedicated website

Promotional materials including a dedicated website, responsible partner: PB, M6

Publications

Peer reviewed articles (27)

The Unfolded Protein Response and Autophagy as Drug Targets in Neuropsychiatric Disorders.

Author(s): Srinivasan V, Korhonen L, Lindholm D.
Published in: Front Cell Neurosci., 2020, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.554548

Sphingolipids as Modulators of SARS-CoV-2 Infection.

Author(s): Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D.
Published in: Front Cell Dev, 2021, ISSN 2296-634X
Publisher: Frontiers Media S.A
DOI: 10.3389/fcell.2021.689854

Daughterless, the Drosophila orthologue of TCF4, is required for associative learning and maintenance of the synaptic proteome

Author(s): Tamberg, Laura; Jaago, Mariliis; Säälik, Kristi; Shubina, Anastassia; Kiir, Carl Sander; Sirp, Alex; Timmusk, Tõnis; Palgi, Mari
Published in: Disease Models & Mechanisms, 2020, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.042747

The Fuchs corneal dystrophy-associated CTG repeat expansion in the TCF4 gene affects transcription from its alternative promoters

Author(s): Alex Sirp, Kristian Leite, Jürgen Tuvikene, Kaja Nurm, Mari Sepp & Tõnis Timmusk
Published in: Scientific Reports, 2020, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-020-75437-3

PGC-1α Signaling Increases GABA(A) Receptor Subunit α2 Expression, GABAergic Neurotransmission and Anxiety-Like Behavior in Mice.

Author(s): Vanaveski T, Molchanova S, Pham DD, Schäfer A, Pajanoja C, Narvik J, Srinivasan V, Urb M, Koivisto M, Vasar E, Timmusk T, Minkeviciene R, Eriksson O, Lalowski M, Taira T, Korhonen L, Voikar V, Lindholm D
Published in: Front Mol Neurosci., 2021, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2021.588230

Antibody response to oral biofilm is a biomarker for acute coronary syndrome in periodontal disease

Author(s): Jaago M, Pupina N, Rähni A, Pihlak A, Sadam H, Vrana NE, Sinisalo J, Pussinen P, Palm K
Published in: Commun Biol., 2022, ISSN 2399-3642
Publisher: Nature Portfolio
DOI: 10.1038/s42003-022-03122-4

Functional Annotation of Custom Transcriptomes.

Author(s): Hamid, F., Alasoo, K., Vilo, J., Makeyev, E
Published in: Methods in Molecular Biology, 2022, ISSN 1064-3745
Publisher: Humana Press, Inc.
DOI: 10.1007/978-1-0716-2521-7_9

Intronic enhancer region governs transcript-specific Bdnf expression in rodent neurons

Author(s): Jürgen Tuvikene Eli-Eelika Esvald Annika Rähni Kaie Uustalu Anna Zhuravskaya Annela Avarlaid Eugene V Makeyev Tõnis Timmusk
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.65161

A conserved role for the ALS-linked splicing factor SFPQ in repression of pathogenic cryptic last exons

Author(s): Patricia M. Gordon, Fursham Hamid, Eugene V. Makeyev & Corinne Houart
Published in: Nature Communications, Issue 12, 2021, Page(s) 1918, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22098-z

Hybridization-proximity labeling reveals spatially ordered interactions of nuclear RNA compartments

Author(s): Karen Yap; Tek Hong Chung;Eugene V. Makeyev;
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.10.009

Functional consequences of TCF4 missense substitutions associated with Pitt-Hopkins syndrome, mild intellectual disability, and schizophrenia

Author(s): Alex Sirp, Kaisa Roots, Kaja Nurm, Jürgen Tuvikene, Mari Sepp and Tõnis Timmusk
Published in: Journal of Biological Chemistry, Issue 297, 2021, Page(s) 101381, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1016/j.jbc.2021.101381

Immune response to a conserved enteroviral epitope of the major capsid VP1 protein is associated with lower risk of cardiovascular disease.

Author(s): Pupina N, Avarlaid A, Sadam H, Pihlak A, Jaago M, Tuvikene J, Rähni A, Planken A, Planken M, Kalso E, Tienari PJ, Nieminen JK, Seppänen MRJ, Vaheri A, Lindholm D, Sinisalo J, Pussinen P, Timmusk T, Palm K.
Published in: EBioMedicine, Issue 23523964, 2022, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.103835

A transcriptome-wide antitermination mechanism sustaining identity of embryonic stem cells

Author(s): Yaroslav A. Kainov, Eugene V. Makeyev
Published in: Nature Communications, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-14204-z

The Intellectual Disability and Schizophrenia Associated Transcription Factor TCF4 Is Regulated by Neuronal Activity and Protein Kinase A

Author(s): Mari Sepp, Hanna Vihma, Kaja Nurm, Mari Urb, Stephanie Cerceo Page, Kaisa Roots, Anu Hark, Brady J. Maher, Priit Pruunsild, Tõnis Timmusk
Published in: The Journal of Neuroscience, Issue 37/43, 2017, Page(s) 10516-10527, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/JNEUROSCI.1151-17.2017

Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion

Author(s): Mehroz Ehsan, Matthew Kelly, Charlotte Hooper, Arash Yavari, Julia Beglov, Mohamed Bellahcene, Kirandeep Ghataorhe, Giulia Poloni, Anuj Goel, Theodosios Kyriakou, Karin Fleischanderl, Elisabeth Ehler, Eugene Makeyev, Stephan Lange, Houman Ashrafian, Charles Redwood, Benjamin Davies, Hugh Watkins, Katja Gehmlich
Published in: Journal of Molecular and Cellular Cardiology, Issue 121, 2018, Page(s) 287-296, ISSN 0022-2828
Publisher: Academic Press
DOI: 10.1016/j.yjmcc.2018.07.248

Recent Insights into the Role of Unfolded Protein Response in ER Stress in Health and Disease

Author(s): Dan Lindholm, Laura Korhonen, Ove Eriksson, Sulev Kõks
Published in: Frontiers in Cell and Developmental Biology, Issue 5, 2017, ISSN 2296-634X
Publisher: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2017.00048

Altered Expression Profile of IgLON Family of Neural Cell Adhesion Molecules in the Dorsolateral Prefrontal Cortex of Schizophrenic Patients

Author(s): Karina Karis, Kattri-Liis Eskla, Maria Kaare, Karin Täht, Jana Tuusov, Tanel Visnapuu, Jürgen Innos, Mohan Jayaram, Tõnis Timmusk, Cynthia S. Weickert, Marika Väli, Eero Vasar, Mari-Anne Philips
Published in: Frontiers in Molecular Neuroscience, Issue 11, 2018, ISSN 1662-5099
Publisher: Frontiers Research Foundation
DOI: 10.3389/fnmol.2018.00008

Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling

Author(s): Helle Sadam, Arno Pihlak, Anri Kivil, Susan Pihelgas, Mariliis Jaago, Priit Adler, Jaak Vilo, Olli Vapalahti, Toomas Neuman, Dan Lindholm, Markku Partinen, Antti Vaheri, Kaia Palm
Published in: EBioMedicine, Issue 29, 2018, Page(s) 47-59, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2018.01.043

Recent advances in applying mass spectrometry and systems biology to determine brain dynamics

Author(s): Enzo Scifo, Giulio Calza, Martin Fuhrmann, Rabah Soliymani, Marc Baumann, Maciej Lalowski
Published in: Expert Review of Proteomics, Issue 14/6, 2017, Page(s) 545-559, ISSN 1478-9450
Publisher: Future Drugs Ltd.
DOI: 10.1080/14789450.2017.1335200

A Short Tandem Repeat-Enriched RNA Assembles a Nuclear Compartment to Control Alternative Splicing and Promote Cell Survival

Author(s): Karen Yap, Svetlana Mukhina, Gen Zhang, Jason S.C. Tan, Hong Sheng Ong, Eugene V. Makeyev
Published in: Molecular Cell, Issue 72/3, 2018, Page(s) 525-540.e13, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2018.08.041

CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons

Author(s): Eli-Eelika Esvald, Jürgen Tuvikene, Alex Sirp, Sudarshan Patil, Clive R. Bramham, Tõnis Timmusk
Published in: The Journal of Neuroscience, 2020, Page(s) 0367-19, ISSN 0270-6474
Publisher: Society for Neuroscience
DOI: 10.1523/jneurosci.0367-19.2019

Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.

Author(s): Nurm K, Sepp M, Castany-Pladevall C, Creus-Muncunill J, Tuvikene J, Sirp A, Vihma H, Blake DJ, Perez-Navarro E, Timmusk T
Published in: eNeuro, 2021, ISSN 2373-2822
Publisher: Society for Neuroscience
DOI: 10.1523/eneuro.0197-21.2021

Identification of two highly antigenic epitope markers predicting multiple sclerosis in optic neuritis patients.

Author(s): Sadam H, Pihlak A, Jaago M, Pupina N, Rähni A, Toots M, Vaheri A, Nieminen JK, Siuko M, Tienari PJ, Palm K.
Published in: EBioMedicine, 2021, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2021.103211

Melanoma-specific antigen-associated antitumor antibody reactivity as an immune-related biomarker for targeted immunotherapies.

Author(s): Rähni A, Jaago M, Sadam H, Pupina N, Pihlak A, Tuvikene J, Annuk M, Mägi A, Timmusk T, Ghaemmaghami AM, Palm K.
Published in: Commun Med, 2022, ISSN 2730-664X
Publisher: Springer
DOI: 10.1038/s43856-022-00114-7

Differential patterns of cross-reactive antibody response against SARS-CoV-2 spike protein detected for chronically ill and healthy COVID-19 naïve individuals.

Author(s): Jaago M, Rähni A, Pupina N, Pihlak A, Sadam H, Tuvikene J, Avarlaid A, Planken A, Planken M, Haring L, Vasar E, Baćević M, Lambert F, Kalso E, Pussinen P, Tienari PJ, Vaheri A, Lindholm D, Timmusk T, Ghaemmaghami AM, Palm K.
Published in: SciRep, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-20849-6

Analysis of RNA-containing compartments by hybridization and proximity labeling in cultured human cells

Author(s): Karen Yap; Tek Hong Chung; Eugene V. Makeyev;
Published in: STAR Protocols, 2022, ISSN 2666-1667
Publisher: Elsevier
DOI: 10.1016/j.xpro.2022.101139

Tuba8 drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini.

Author(s): Ramos SI, Makeyev EV, Salierno M, Kodama T, Kawakami Y, Sahara S. Tuba
Published in: Dev Cell, Issue 15345807, 2020, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2020.01.036

Other (1)

High seroreactivity against SARS-CoV-2 Spike epitopes in a pre SARS-CoV-2 cohort: implications for antibody testing and vaccine design

Author(s): Kaia Palm; Mariliis Jaago; Annika Rähnni, Nadezhda Pupina; Arno Pihlak; Helle Sadam; Annela Avarlaid; Anu Planken; Planken; Liina Haring; Eero Vasar; Miljana Bacevic; Eija Kalso; Pirkko J. Pussinen; Pentti J. Tienari;Antti Vaheri; Dan Lindholm; Tõnis Timmusk; Amir M. Ghaemmaghami;ni;
Published in: 2020
Publisher: Cold Spring Harbor Laboratory
DOI: 10.1101/2020.05.18.20105189