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Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

Ziel

Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.

Wissenschaftliches Gebiet

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

H2020-SFS-2016-2017

Andere Projekte für diesen Aufruf anzeigen

Unterauftrag

H2020-SFS-2016-2

Finanzierungsplan

RIA - Research and Innovation action

Koordinator

STICHTING RADBOUD UNIVERSITAIR MEDISCH CENTRUM
Netto-EU-Beitrag
€ 1 519 700,34
Adresse
GEERT GROOTEPLEIN 10 ZUID
6525 GA Nijmegen
Niederlande

Auf der Karte ansehen
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Aktivitätstyp
Higher or Secondary Education Establishments
Links
Gesamtkosten
€ 1 519 700,34

Beteiligte (20)

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Letzte Aktualisierung: 30 Januar 2024

Mein Booklet

Permalink: https://cordis.europa.eu/project/id/728018/de

European Union, 2024